Document Detail

Transketolase and 2-oxoglutarate dehydrogenase activities in the brain and liver of the developing rat.
MedLine Citation:
PMID:  3416997     Owner:  NLM     Status:  MEDLINE    
Rat brain transketolase showed little change in activity from birth to adulthood, whereas the liver enzyme activity increased in a biphasic way. In both brain and liver, 2-oxoglutarate dehydrogenase activity increased gradually after birth and reached a plateau at 5 weeks of age. A developmental change in thiamin content in the brain was similar to the change in the 2-oxoglutarate dehydrogenase activity, but this was not the case in the liver.
H Iwata; H Tonomura; T Matsuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  44     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-27     Completed Date:  1988-10-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  780-1     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
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MeSH Terms
Brain / enzymology*
Ketoglutarate Dehydrogenase Complex / metabolism*
Ketone Oxidoreductases / metabolism*
Liver / enzymology*
Rats, Inbred Strains / growth & development*
Thiamine / physiology
Transketolase / metabolism*
Reg. No./Substance:
59-43-8/Thiamine; EC 1.2.-/Ketone Oxidoreductases; EC Dehydrogenase Complex; EC

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