| Transitory interruption of recommended storage conditions does not cause significant changes in in vitro parameters of leucocyte-depleted red blood cells. | |
| | |
MedLine Citation:
|
PMID: 20860559 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background and Objectives Conventional quality control studies of the shelf life of RBC units do not consider cold chain interruptions that occur during cross-matching or between the release of RBCs from the blood bank and their return from the ward. These interruptions may, however, lead to a considerable loss of quality. On the other hand, differences in the quality of RBCs may derive from the different manufacturing processes employed in various blood centres. Materials and Methods One day after the expiry date of the RBC unit, we analysed complete blood count, blood gas, potassium, LDH, hydroxybutyrate dehydrogenase, glucose, lactate, total and free haemoglobin (Hb) and ATP and compared the results with regard to the frequency of storage interruptions and to two manufacturers of these RBCs. Results We could not find any correlations between the frequency of interruptions (0-11) and these parameters in any of the data sets. However, we found significant differences when comparing the two suppliers. RBCs of manufacturer A ('A', inline filtration of whole blood) contained 25% more Hb than those of manufacturer B ('B', inline filtration after buffy coat reduction). Sixteen percentage of 'A'-RBC, but none of 'B'-RBC, exceeded a haemolysis of 0·8%. Conclusions Transitory interruptions of cold chain do not measurably impair the quality of RBCs. The effect on storage of RBCs in the blood bank is not as significant a factor as the differences that exist between RBC manufacturing procedures. |
| | |
Authors:
|
D R Weiss; S Fortenbacher; J Ringwald; E F Strasser; R Zimmermann; R Eckstein |
Related Documents
:
|
2060999 - Aggregation of microspheres in blood flow measurements. 9508279 - Nmr studies of intra- and extracellular red blood cell lithium by transverse relaxation... 393789 - Pentoxifylline -- a biomedical profile. 2978119 - Theoretical and experimental study of the time dependent flow of red blood cell suspens... 6182069 - Integral viscosity: a useful parameter in evaluating whole blood and plasma viscosities... 65499 - Changes in blood viscosity and plasma proteins in carcinoma. 2060999 - Aggregation of microspheres in blood flow measurements. 15947479 - Rantes and eotaxin enhance cd11b and cd18 expression on eosinophils from allergic patie... 21604079 - Single brain death examination is equivalent to dual brain death examinations. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-22 |
Journal Detail:
|
Title: Vox sanguinis Volume: 100 ISSN: 1423-0410 ISO Abbreviation: Vox Sang. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: England |
Other Details:
|
Languages: eng Pagination: 272-8 Citation Subset: IM |
Copyright Information:
|
© 2010 The Author(s). Vox Sanguinis © 2010 International Society of Blood Transfusion. |
Affiliation:
|
Department of Transfusion Medicine and Haemostaseology, University Hospital Erlangen, Erlangen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microarray and allergenic activity assessment of milk allergens.
Next Document: Influence of late irradiation on the in vitro RBC storage variables of leucoreduced RBCs in SAGM add...