| Transitional changes in T-cell responses to Mycobacterium tuberculosis-specific antigens during treatment. | |
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MedLine Citation:
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PMID: 18848730 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Currently, there is no available test for monitoring the clinical effect of active tuberculosis (TB) disease treatment. Therefore, we studied the usefulness of two commercial IFN-gamma assays (QuantiFERON TB-2G (QFT-2G) and T-SPOT.TB tests) for monitoring clinical efficacy. METHODS: The subjects were 40 patients with active TB disease. These two commercial IFN-gamma assays were carried out every three months during active TB disease treatment. RESULTS: While the positive response rate of QFT-2G test significantly decreased from 83% at treatment initiation to 58% at treatment completion, that of T-SPOT.TB decreased from 90% at treatment initiation to 63% at treatment completion. Although there was a significant decrease in patients with TB infection showing positive responses for ESAT-6 only or CFP-10 only antigens on both IFN-gamma assays, there was no significant decrease in patients showing positive responses for both ESAT-6 and CFP-10 antigens on both IFN-gamma assays. On both QFT-2G test and T-SPOT.TB test, the mean values of the IFN-gamma levels in the pre- and post-treatment responses showed significantly decreased responses to CFP-10. On the other hand, smear conversion results of clinical specimens were obtained in all patients at treatment completion. CONCLUSIONS: Antituberculous treatment induced a significant decrease in T-cell responses to separate ESAT-6 and CFP-10 antigens as measured by both IFN-gamma assays. Although IFN-gamma assays might be later than smear conversion results of clinical specimens, the quantitative responses especially to CFP-10 may be one of the useful monitoring markers of clinical efficacy for active TB disease treatment. |
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Authors:
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Yoshihiro Kobashi; Keiji Mouri; Shinichi Yagi; Yasushi Obase; Naoyuki Miyashita; Mikio Oka |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2008-10-10 |
Journal Detail:
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Title: The Journal of infection Volume: 58 ISSN: 1532-2742 ISO Abbreviation: J. Infect. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-09 Completed Date: 2009-04-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: England |
Other Details:
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Languages: eng Pagination: 197-204 Citation Subset: IM |
Affiliation:
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Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan. yoshihiro@med.kawasaki-m.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, Bacterial / immunology Antitubercular Agents / immunology*, therapeutic use* Bacterial Proteins / immunology Drug Monitoring / methods* Female Humans Interferon-gamma / secretion Male Middle Aged Mycobacterium tuberculosis / immunology Sputum / microbiology T-Lymphocytes / immunology* Tuberculosis / drug therapy*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Antitubercular Agents; 0/Bacterial Proteins; 0/CFP-10 protein, Mycobacterium tuberculosis; 0/ESAT-6 protein, Mycobacterium tuberculosis; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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