| Transitional angiogenesis and vascular remodeling during coronary angiogenesis in response to myocardial infarction. | |
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MedLine Citation:
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PMID: 17014894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery disease (CAD) is a major source of morbidity and mortality in the industrialized world. CAD causes ischemia as a prelude to angina, myocardial infarction and heart failure as specific forms of heart disease causing a decline in the quality of life. CAD or atherosclerosis and the resulting myocardial ischemia trigger a natural angiogenic response that generates collateral circulations. The long-term goal for these studies is to develop therapeutic angiogenesis that augments the natural coronary angiogenesis. This project makes use of an infarcted transgenic mouse model to characterize formation of those collateral circulations in the post-infraction heart. The experiments utilized thoracotomy and a microcauterizer to produce an infarct in transgenic mice and this stimulated neovascularization and allowed labeling of the coronary vessels, thereby defining the morphogenic processes involved in formation of collateral circulations. The results show that the heart consistently responds to infarcts with angiogenesis at 1d post-treatment (PT) that undergoes transition into vascular remodeling at 7d PT with complete remodeling at 14d PT. The vascular remodeling appears to mitigate any net increase in perfusion that may be achieved early in coronary angiogenesis. The results suggest that therapeutic approaches need to shift from an exclusive focus on stimulating angiogenesis to include modulation of vascular remodeling for increased long-term myocardial perfusion. |
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Authors:
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Taren M Grass; Diana I Lurie; J Douglas Coffin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2006-10-02 |
Journal Detail:
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Title: Acta histochemica Volume: 108 ISSN: 0065-1281 ISO Abbreviation: Acta Histochem. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2007-02-09 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0370320 Medline TA: Acta Histochem Country: Germany |
Other Details:
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Languages: eng Pagination: 293-302 Citation Subset: IM |
Affiliation:
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Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences, SB244, The University of Montana, Missoula, MT 59812, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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analysis Animals Coronary Vessels / pathology, physiopathology* Disease Models, Animal Disease Progression Immunohistochemistry / methods Mice Mice, Transgenic Myocardial Infarction / pathology*, physiopathology Myocardium / pathology* Neovascularization, Physiologic* Staining and Labeling / methods Ventricular Remodeling |
| Grant Support | |
ID/Acronym/Agency:
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1P20RR17670-01/RR/NCRR NIH HHS; HL53631/HL/NHLBI NIH HHS; R01CCR822092-01//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Actins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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