| Transition from primary Raynaud's phenomenon to secondary Raynaud's phenomenon identified by diagnosis of an associated disease: results of ten years of prospective surveillance. | |
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MedLine Citation:
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PMID: 16732585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the early signs, risk factors, and rate of transition from primary Raynaud's phenomenon (primary RP) to secondary RP. METHODS: A clinical sample of 307 consecutive patients with RP was included in a prospective followup study. After an initial screening, 244 patients were classified as having primary RP, of whom 236 were followed up for a mean +/- SD of 11.2 +/- 3.9 years. Patients classified according to the screening as having suspected secondary RP underwent an extended screening program annually until transition to secondary RP occurred. RESULTS: The initial prevalence of secondary RP was 11%. The annual incidence of transition to suspected secondary RP was 2%, and the annual incidence of transition to secondary RP was 1%. Overall, 46 patients were classified as having suspected secondary RP, and 23 of these later were classified as having secondary RP. Older age at onset of RP (hazard ratio 2.59, 95% confidence interval [95% CI] 1.40-4.80), shorter duration of RP at enrollment (hazard ratio 0.87, 95% CI 0.81-0.94), and abnormal findings on thoracic outlet test (hazard ratio 2.69, 95% CI 1.12-6.48) were associated with an increased risk for transition to secondary RP. Compared with patients with suspected secondary RP, those diagnosed as having secondary RP had a higher number and earlier occurrence of pathologic findings. Furthermore, antinuclear antibodies at a titer of > or = 1:320 and positive findings in specific serologic subsets were associated with a significantly increased risk for developing a connective tissue disease. CONCLUSION: Patients diagnosed initially as having primary RP may actually comprise 1 of 3 groups: those with idiopathic RP, those with a rather benign disease course, and those with a more severe course of the disease. |
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Authors:
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Mirko Hirschl; Katharina Hirschl; Matthias Lenz; Reinhold Katzenschlager; Hans-Peter Hutter; Michael Kundi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 54 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-19 Completed Date: 2006-07-14 Revised Date: 2008-01-18 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 1974-81 Citation Subset: AIM; IM |
Affiliation:
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Hanuschkrankenhaus, Vienna, Austria. Mirko.Hirschl@wgkk.sozvers.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antinuclear / blood Female Follow-Up Studies Humans Male Middle Aged Prospective Studies Raynaud Disease / classification, diagnosis*, immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear |
| Comments/Corrections | |
Comment In:
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Arthritis Rheum. 2007 Jun;56(6):2102-3; author reply 2103-4
[PMID:
17530659
]
Perspect Vasc Surg Endovasc Ther. 2007 Sep;19(3):341-2 [PMID: 17911571 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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