Document Detail

Transition from overweight to obesity worsens pregnancy outcome in a BMI-dependent manner.
MedLine Citation:
PMID:  16493135     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess pregnancy outcomes in different BMI groups. RESEARCH METHODS AND PROCEDURES: We analyzed 25,601 singleton pregnancies from January 1989 to December 2001. Overweight women (prepregnancy BMI = 26 to 29 kg/m2) represented 13.2% (3388) of the cases, and 7.3% (1880) were obese (BMI > or = 30 kg/m2). The data were obtained from self-administered questionnaires at 20 weeks of pregnancy, complemented by nurse interviews and clinical records. Multiple logistic regression analysis was used to control for confounding factors. RESULTS: Overweight and obese women had more previous deliveries, pregnancy terminations, miscarriages, and stillbirths, to have more diabetes and hypertension, and to smoke more often than normal weight women. The pregnancies were more often complicated by preeclampsia or chorioamnionitis (p < 0.001). Pregnancy outcomes were impaired in overweight and obese pregnant women, with respective odds ratios (95% confidence index) as follows: low Apgar score at 5 minutes, 1.54 (1.20 to 1.98) and 1.64 (1.22 to 2.28); newborn admission to a neonatal unit, 1.20 (1.06 to 1.37) and 1.38 (1.17 to 1.61); cesarean delivery, 1.22 (1.10 to 1.35) and 1.68 (1.48 to 1.91); fetal death, 1.54 (0.88 to 2.68) and 2.35 (1.28 to 4.32); perinatal death, 1.54 (0.98 to 2.42) and 2.19 (1.33 to 3.62). DISCUSSION: Obesity, in particular during pregnancy, should be considered as an abnormal situation. An overweight condition increases obstetric risks in a BMI-dependent manner. The risk of perinatal death more than doubles in the transition from an overweight to an obese condition. Modest weight loss could bring substantial advantages to obstetric outcome.
Kaisa Raatikainen; Nonna Heiskanen; Seppo Heinonen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  14     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-22     Completed Date:  2006-08-08     Revised Date:  2008-01-21    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland.
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MeSH Terms
Apgar Score
Body Mass Index
Finland / epidemiology
Hospitals, Maternity / statistics & numerical data*
Infant, Newborn
Logistic Models
Obesity / complications*
Obstetric Labor Complications / epidemiology*
Odds Ratio
Pregnancy Complications / epidemiology*,  etiology
Pregnancy Outcome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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