Document Detail


Transition from organogenesis to stem cell maintenance in the mouse adrenal cortex.
MedLine Citation:
PMID:  22198434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mice showing mosaic expression of an appropriate marker gene that is activated during development provide simple tools for investigating cell lineages. We used the mosaic β-galactosidase staining patterns in adrenal cortices of 21OH/ LacZ transgenic mice to study both organogenesis and maintenance of the adult tissue. Randomly orientated mosaic patterns present in embryonic day 14.5 (E14.5) adrenals changed progressively during the perinatal period from discrete spots, via patches and radial arrays, to radial stripes, which first emerged between postnatal days 0 and 7 (P0 and P7). The mosaic radial stripe pattern was fully established by P21 and remained unchanged throughout the adult period (8-52 weeks). The mouse adrenal gland grew continuously between E14.5 and P21, including the period during which stripes emerge. Ki67-positive, proliferative cells in the adrenal cortex were mainly localized to the outer cell layers between E18.5 and P3. By P10, cell proliferation had increased, and the proliferative region had expanded but was still mainly confined to the outer cortex. Correlation of changes in mosaic patterns in 21OH/LacZ adrenal cortices with the locations of adrenocortical cell proliferation suggest that the radial stripes arise by edge-biased growth during the perinatal period, even if they are maintained by stem cells in adults. The stability of the adult stripe pattern suggests that stem cell function is unchanged between 8 and 52 weeks.
Authors:
Su-Ping Chang; John J Mullins; Steven D Morley; John D West
Related Documents :
12791154 - Effects of two vitamins, two growth factors and dexamethasone on the proliferation of r...
15456744 - Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.
11734594 - Role of fibroblast growth factor receptor signaling in prostate cancer cell survival.
16957024 - Effects of 25-hydroxyvitamin d3 and 1,25-dihydroxyvitamin d3 on cytokine production by ...
9185714 - A lymphocyte cell surface heat shock protein homologous to the endoplasmic reticulum ch...
8535214 - Quantitative expression of proliferating cell nuclear antigen by western blot (pcnawb) ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organogenesis     Volume:  7     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:    2011 Oct-Dec
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-08-08     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-80     Citation Subset:  IM    
Affiliation:
Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Edinburgh, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex / cytology*,  embryology*
Animals
Animals, Newborn
Body Patterning
Cell Proliferation
Female
Fetus / embryology
Ki-67 Antigen / metabolism
Male
Mice
Mice, Transgenic
Models, Biological
Organogenesis*
Stem Cells / cytology*,  metabolism*
beta-Galactosidase / metabolism
Grant Support
ID/Acronym/Agency:
053646/Z/98/C//Wellcome Trust
Chemical
Reg. No./Substance:
0/Ki-67 Antigen; EC 3.2.1.23/beta-Galactosidase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Wnt/planar cell polarity signaling: an important mechanism to coordinate growth and patterning in th...
Next Document:  Structural differences in the osteocyte network between the calvaria and long bone revealed by three...