Document Detail


Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: Structure, function, and transcript analysis.
MedLine Citation:
PMID:  20006699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gene expression, determined by micro-array analysis, and left ventricular (LV) remodeling associated with the transition to systolic heart failure (HF) were examined in the spontaneously hypertensive rat (SHR). By combining transcript and gene set enrichment analysis (GSEA) of the LV with assessment of function and structure in age-matched SHR with and without HF, we aimed to better understand the molecular events underlying the onset of hypertensive HF. Failing hearts demonstrated depressed LV ejection fraction, systolic blood pressure, and LV papillary muscle force while LV end-diastolic and systolic volume and ventricular mass increased. 1431 transcripts were differentially expressed between failing and non-failing animals. GSEA identified multiple enriched gene sets, including those involving inflammation, oxidative stress, cell degradation and cell death, as well as TGF-beta and insulin signaling pathways. Our findings support the concept that these pathways and mechanisms may contribute to deterioration of cardiac function and remodeling associated with hypertensive HF.
Authors:
Wesley W Brooks; Steven S Shen; Chester H Conrad; Ronald H Goldstein; Oscar H L Bing
Related Documents :
18082469 - Early and late effects of cardiac resynchronization therapy on force-frequency relation...
9300289 - Assessment of left atrial operative mean stiffness using simultaneous recordings of lef...
12821259 - Left ventricular structural and functional characteristics in cushing's syndrome.
17339549 - Global diastolic strain rate for the assessment of left ventricular relaxation and fill...
3044189 - Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilat...
12906989 - Intra-ventricular resynchronization for optimal left ventricular function during pacing...
603879 - Failure of saralasin acetate, a competitive inhibitor of angiotensin ii, to diminish al...
16282869 - Associations between submicrometer particles exposures and blood pressure and heart rat...
17747489 - Effect of a coordination change on the strength of amorphous sio2.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-16
Journal Detail:
Title:  Genomics     Volume:  95     ISSN:  1089-8646     ISO Abbreviation:  Genomics     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-92     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
VA Boston Healthcare System, Boston, MA 02130, USA. wesley.brooks@va.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomegaly / complications*
Heart Failure, Systolic / etiology*
Hypertension / complications*,  genetics
Male
Rats
Rats, Inbred SHR
Transcription, Genetic
Ventricular Remodeling / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acrylamide catalytically inhibits topoisomerase II in V79 cells.
Next Document:  Spinally applied ketamine or morphine attenuate peripheral inflammation and hyperalgesia in acute an...