Document Detail


Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: Structure, function, and transcript analysis.
MedLine Citation:
PMID:  20006699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gene expression, determined by micro-array analysis, and left ventricular (LV) remodeling associated with the transition to systolic heart failure (HF) were examined in the spontaneously hypertensive rat (SHR). By combining transcript and gene set enrichment analysis (GSEA) of the LV with assessment of function and structure in age-matched SHR with and without HF, we aimed to better understand the molecular events underlying the onset of hypertensive HF. Failing hearts demonstrated depressed LV ejection fraction, systolic blood pressure, and LV papillary muscle force while LV end-diastolic and systolic volume and ventricular mass increased. 1431 transcripts were differentially expressed between failing and non-failing animals. GSEA identified multiple enriched gene sets, including those involving inflammation, oxidative stress, cell degradation and cell death, as well as TGF-beta and insulin signaling pathways. Our findings support the concept that these pathways and mechanisms may contribute to deterioration of cardiac function and remodeling associated with hypertensive HF.
Authors:
Wesley W Brooks; Steven S Shen; Chester H Conrad; Ronald H Goldstein; Oscar H L Bing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-16
Journal Detail:
Title:  Genomics     Volume:  95     ISSN:  1089-8646     ISO Abbreviation:  Genomics     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-92     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
VA Boston Healthcare System, Boston, MA 02130, USA. wesley.brooks@va.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomegaly / complications*
Heart Failure, Systolic / etiology*
Hypertension / complications*,  genetics
Male
Rats
Rats, Inbred SHR
Transcription, Genetic
Ventricular Remodeling / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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