Document Detail


Transition-Metal-free Hydroamination Reaction of N-Substituted-2-Alkynamides with Hydrazides via Sequential Ugi/Nucleophilic Addition Reaction.
MedLine Citation:
PMID:  23734677     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, primary amines, propiolic acid, isocyanides and hydrazides has been developed in order to access polyfunctional pseudopeptides. The reaction may proceed through formation of N-substituted-2-alkynamides as intermediates. This process is found to be mild and operationally simple with broad substrate scope.
Authors:
Shokoofeh Maghari; Sorour Ramezanpour; Saeed Balalaie; Fatemeh Darvish; Frank Rominger; Hamid Reza Bijanzadeh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-5
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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