| Transintestinal cholesterol efflux. | |
| | |
MedLine Citation:
|
PMID: 20410820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Regulation of cholesterol homeostasis is a complex interplay of a multitude of metabolic pathways situated in different organs. The liver plays a central role and has received most attention of the research community. In this review, we discuss recent progress in the understanding of the emerging role of the intestine in cholesterol transport. RECENT FINDINGS: In recent years, insight in the transport systems that mediate intestinal cholesterol excretion has deepened considerably. Evidence is emerging that the proximal part of the small intestine is able to secrete cholesterol actively, a pathway called transintestinal cholesterol efflux (TICE). In mice, TICE accounts for up to 70% of fecal neutral sterol excretion. SUMMARY: The small intestine plays a significant role in the regulation of body cholesterol homeostasis. Active processes control both absorption and excretion of the sterol and the pathways involved are being elucidated. TICE might provide an attractive target for therapy aiming at reduction of atherosclerosis. |
| | |
Authors:
|
Astrid E van der Velde; Gemma Brufau; Albert K Groen |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in lipidology Volume: 21 ISSN: 1473-6535 ISO Abbreviation: Curr. Opin. Lipidol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-13 Completed Date: 2010-08-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010000 Medline TA: Curr Opin Lipidol Country: England |
Other Details:
|
Languages: eng Pagination: 167-71 Citation Subset: IM |
Affiliation:
|
Academic Medical Center, AMC Liver Center, Amsterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Transport Cholesterol / metabolism* Diet Humans Intestines / metabolism* |
| Chemical | |
Reg. No./Substance:
|
57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Food allergy and eosinophilic esophagitis.
Next Document: Adipose tissue recruitment of leukocytes.