| Transient ventricular wall thickening in acute myocarditis: a serial echocardiographic and histopathologic study. | |
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MedLine Citation:
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PMID: 11665789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to determine whether the wall thickening seen in acute myocarditis is caused by interstitial edema. The study group comprised 25 patients (idiopathic myocarditis, 17; eosinophilic myocarditis, 8) in whom acute myocarditis was diagnosed histologically and who underwent echocardiography and endomyocardial biopsy during both the acute and convalescent phases. The following echocardiographic parameters were measured: interventricular septum and left ventricular posterior wall thickness, left ventricular end-diastolic dimension, and left ventricular ejection fraction. Based on the myocardial biopsy specimens, the degree of interstitial edema was classified into 3 grades [(-), 1(+), 2(+)] and the transverse diameter of cardiac myocytes was measured using light microscopy. The thickness of both the interventricular septum and left ventricular wall decreased from 14.3+/-3.7 mm and 13.3+/-2.4 mm in the acute phase to 9.7+/-1.7 mm (p<0.001) and 10.2+/-1.7 mm (p<0.0001), respectively, in the convalescent phase. Edema was present in 22 patients (88.0%) in the acute phase, but in the convalescent phase, edema was present in only 7 patients (28.0%), indicating a significant reduction in the degree of edema (p<0.0001). Cardiac myocyte diameter did not differ significantly between the acute (13.6+/-1.1 microm) and convalescent (13.8+/-1.8 microm) phases. |
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Authors:
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S Hiramitsu; S Morimoto; S Kato; A Uemura; N Kubo; K Kimura; A Sugiura; T Itoh; H Hishida |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Review |
Journal Detail:
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Title: Japanese circulation journal Volume: 65 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-22 Completed Date: 2002-11-19 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: Australia |
Other Details:
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Languages: eng Pagination: 863-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Biopsy Cell Size Child Echocardiography Edema, Cardiac / pathology Female Humans Male Middle Aged Myocarditis / pathology*, ultrasonography Myocardium / pathology Statistics, Nonparametric Time Factors Ventricular Remodeling* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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