Document Detail

Transient ventricular wall thickening in acute myocarditis: a serial echocardiographic and histopathologic study.
MedLine Citation:
PMID:  11665789     Owner:  NLM     Status:  MEDLINE    
The present study was designed to determine whether the wall thickening seen in acute myocarditis is caused by interstitial edema. The study group comprised 25 patients (idiopathic myocarditis, 17; eosinophilic myocarditis, 8) in whom acute myocarditis was diagnosed histologically and who underwent echocardiography and endomyocardial biopsy during both the acute and convalescent phases. The following echocardiographic parameters were measured: interventricular septum and left ventricular posterior wall thickness, left ventricular end-diastolic dimension, and left ventricular ejection fraction. Based on the myocardial biopsy specimens, the degree of interstitial edema was classified into 3 grades [(-), 1(+), 2(+)] and the transverse diameter of cardiac myocytes was measured using light microscopy. The thickness of both the interventricular septum and left ventricular wall decreased from 14.3+/-3.7 mm and 13.3+/-2.4 mm in the acute phase to 9.7+/-1.7 mm (p<0.001) and 10.2+/-1.7 mm (p<0.0001), respectively, in the convalescent phase. Edema was present in 22 patients (88.0%) in the acute phase, but in the convalescent phase, edema was present in only 7 patients (28.0%), indicating a significant reduction in the degree of edema (p<0.0001). Cardiac myocyte diameter did not differ significantly between the acute (13.6+/-1.1 microm) and convalescent (13.8+/-1.8 microm) phases.
S Hiramitsu; S Morimoto; S Kato; A Uemura; N Kubo; K Kimura; A Sugiura; T Itoh; H Hishida
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Publication Detail:
Type:  Clinical Trial; Journal Article; Review    
Journal Detail:
Title:  Japanese circulation journal     Volume:  65     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-22     Completed Date:  2002-11-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  863-6     Citation Subset:  IM    
Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
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MeSH Terms
Acute Disease
Cell Size
Edema, Cardiac / pathology
Middle Aged
Myocarditis / pathology*,  ultrasonography
Myocardium / pathology
Statistics, Nonparametric
Time Factors
Ventricular Remodeling*

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