Document Detail


Transient symptomatic zinc deficiency in a breast-fed infant: Relevance of a genetic study.
MedLine Citation:
PMID:  21907902     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: We present a case of acrodermatitis enteropathica in a full-term, breast-fed, 7-mo-old infant born from consanguineous parents with a family history of acrodermatitis enteropathica.
METHODS: The patient presented with periorificial and symmetric acral lesions, which prompted us to review the clinical features of acrodermatitis enteropathica and its pathogenesis. Laboratory investigations showed low zinc levels in the infant's and mother's sera and in the mothers' milk.
RESULTS: A diagnosis of acrodermatitis enteropathica was made. A mutation screening of the SLC39A4 gene in the patient and his mother showed heterozygosity for the deletion c.1223_1227delCCGGG. The diagnosis of transient symptomatic zinc deficiency was then established.
CONCLUSION: Transient symptomatic zinc deficiency is generally reported in premature infants but should also be considered in full-term, breast-fed infants, as in the present case.
Authors:
Nadia El Fékih; Kharfi Monia; Sebastien Schmitt; Iméne Dorbani; Sébastien Küry; Mohamed R Kamoun
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  27     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1087-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Dermatology, Hôpital Charles Nicolle, Tunis, Tunisia.
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