Document Detail

Transient suppression of seizures by repetitive transcranial magnetic stimulation in a case of Rasmussen's encephalitis.
MedLine Citation:
PMID:  18304879     Owner:  NLM     Status:  MEDLINE    
Repetitive transcranial magnetic stimulation (rTMS) has been applied with variable success to terminate the seizures of epilepsia partialis continua. The rationale for using this technique to suppress ongoing seizures is the capacity of rTMS to interrupt ongoing neuronal activity, and to produce a lasting decrease in cortical excitability with low-frequency (1 Hz) stimulation. We report a case of epilepsia partialis continua in a child with Rasmussen's encephalitis, in whom seizures were transiently suppressed by 1-Hz rTMS delivered in nine daily 30-minute sessions. In this case, total ictal time was significantly reduced during stimulation, but the daily baseline seizure rate remained unchanged. Notably, the detection and quantification of this short-lived improvement were enabled by recording EEG continuously during the rTMS session. Thus, we present this case to illustrate a potential utility of combined continuous EEG recording and rTMS in seizure treatment.
Alexander Rotenberg; Dewi Depositario-Cabacar; Erica Hyunji Bae; Chellamani Harini; Alvaro Pascual-Leone; Masanori Takeoka
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-04
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  13     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-09-04     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  260-2     Citation Subset:  IM    
Division of Epilepsy and Clinical Neurophysiology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Electric Stimulation / methods
Encephalitis / complications
Epilepsia Partialis Continua / etiology,  therapy*
Evoked Potentials, Motor
Transcranial Magnetic Stimulation / methods*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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