Document Detail


Transient stress lymphocytosis during crisis of sickle cell anemia and emergency trauma and medical conditions. An immunophenotyping study.
MedLine Citation:
PMID:  2095748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient absolute lymphocytosis of peripheral blood has been described in "stress"-related emergency trauma and medical conditions. There are no reports of this phenomenon in patients with sickle cell anemia with vaso-occlusive crisis. We studied initial and follow-up immunophenotypic characteristics of 10 adult patients with sickle cell anemia in crisis and 15 adult patients with emergency conditions who presented with absolute lymphocytosis. On admission, both groups demonstrated increases in the numbers of CD20+ B cells and T cells of the CD2, CD4, CD8, and CD56 (NKH-1) phenotypes compared with control values. Findings in both groups of patients mimicked the results of parenteral epinephrine administration: a pan-B and -T lymphocytosis with marked increase in CD56 (fourfold to fivefold) and CD8 cells (threefold to fourfold) as well as moderate increases in CD20 and CD4 cells (twofold), resulting in a decrease in the CD4/CD8 ratio compared with control values. In patients with sickle cell anemia, there was an expected increase in the CD56 and CD4 populations; however, CD8 cells only doubled at the time of crisis. Therefore, the CD4/CD8 ratio was normal compared with control values. CD20+ B cell numbers exceeded those seen in the patients with medical and trauma emergencies. Elevated corticosteroid levels have been measured after injury in previous studies. Parenterally administered cortisol produces a lymphocytopenia after 4 to 6 hours that selectively decreases T cells. At 10 to 38 hours after admission, there was a marked reduction in the number of T cells in both groups of "stressed" patients, probably reflecting at least partial effects of endogenous corticosteroids. In contrast to the patients with medical and trauma emergencies, the mean lymphocyte count in the patients with sickle cell anemia remained elevated in the "high normal" range and consisted of increased numbers of B cells and CD4 cells. This finding persisted in the patients with sickle cell anemia for up to 3 months after presentation. The lymphocyte responses in both groups probably reflect interactions between adrenergic and steroidal factors.
Authors:
D A Groom; L A Kunkel; R K Brynes; J W Parker; C S Johnson; D Endres
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  114     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-03     Completed Date:  1990-07-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  570-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, University of Southern California, Los Angeles.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Anemia, Sickle Cell / blood*,  immunology
Blood Cell Count
Female
Flow Cytometry
Follow-Up Studies
Humans
Hydrocortisone / blood
Leukocyte Count
Lymphocytes / immunology*
Lymphocytosis / blood*,  immunology
Male
Middle Aged
Phenotype
Stress, Physiological / blood*,  immunology
Wounds and Injuries / blood,  immunology
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone
Comments/Corrections
Comment In:
Arch Pathol Lab Med. 1991 Mar;115(3):211   [PMID:  2001154 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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