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Transient reduction and activation of circulating dendritic cells in patients with acute myocardial infarction.
MedLine Citation:
PMID:  22841473     Owner:  NLM     Status:  Publisher    
BACKGROUND: Dendritic cells (DCs) are highly potent professional antigen-presenting cells that play a central role in initiating the primary immune response. Accumulating evidence suggests that immune-mediated inflammation plays an important role in the pathophysiology of AMI, but the mechanism that triggers such immune responses is unknown. METHODS: Using multi-color flow-cytometry, we determined the numbers of circulating myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with AMI (n=26) or stable angina pectoris (SAP) (n=19), and in age-matched control subjects (n=19). The DC activation markers CD40 and CD83 were also measured. RESULTS: On admission, circulating mDC and pDC counts were significantly lower in AMI patients compared to control subjects and SAP patients (mDC, P<0.01; pDC, P<0.05). The activation markers of mDCs in AMI patients were significantly higher and returned to the levels of control subjects or SAP patients 3days after AMI (mDC, P<0.05; pDC, P<0.05). Reductions of circulating mDC and pDC numbers were restored 7days after the onset of AMI. Furthermore, we found that the recovery of the circulating DC numbers 14days after AMI was correlated with the alterations of creatine kinase-MB (CK-MB) (mDC, r=0.48, P<0.05; pDC, r=0.52, P<0.01) and brain natriuretic peptide (BNP) (mDC, r=0.53, P<0.01; pDC, r=0.51, P<0.01). CONCLUSION: Our findings suggest that the transient reduction and activation of circulating DCs may play important roles in the pathophysiology of myocardial injury after AMI.
Daisuke Fukui; Hideo Yasukawa; Yusuke Sugi; Toyoharu Oba; Takanobu Nagata; Sachiko Kyogoku; Nobuyoshi Futamata; Toshiro Yokoyama; Shinji Yokoyama; Hisashi Kai; Takafumi Ueno; Masayoshi Kage; Tsutomu Imaizumi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-27
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume, Japan.
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