Document Detail

Transient receptor potential vanilloid in blood pressure regulation.
MedLine Citation:
PMID:  23274405     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: The involvement of neurohormonal factors in the pathogenesis of hypertension has been extensively studied. However, the mechanisms underlying the role of the transient receptor potential vanilloid type 1 (TRPV1) channels in hypertension are still largely unknown. This review presents some of the most recent findings regarding the potential mechanisms of TRPV1 in mediating blood pressure, the pathophysiology of hypertension, and its related disorders. RECENT FINDINGS: TRPV1 may be activated by exogenous vanilloid or endo-vanilloid compounds and its function modulated by vasoactive mediators. TRPV1 also interacts with various physiological and pathophysiological systems involved in salt and water homeostasis and cardiovascular homeostasis. Impairment of TRPV1 signaling may contribute to the pathogenesis of diseases such as hypertension, heart failure, atherosclerosis, diabetes, obesity, myocardial ischemia, and stroke. SUMMARY: Accumulating evidence implicates TRPV1 as serving a key role in cardiovascular health by regulating cardiovascular function and protecting against cardiovascular injury. Given the large prevalence of hypertension and its related disorders, the possible involvement of TRPV1 makes it a potential target of therapy for cardiovascular disease. Future study of TRPV1 may enhance our understanding of several cardiovascular diseases and may unveil novel pharmacological strategies for treating hypertension.
Michael Hollis; Donna H Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-27
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  -     ISSN:  1535-3842     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medicine, Cell & Molecular Biology Program, Neuroscience Program, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
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