| Transient receptor potential channel type M5 is essential for fat taste. | |
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MedLine Citation:
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PMID: 21653867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Until recently, dietary fat was considered to be tasteless, and its primary sensory attribute was believed to be its texture (Rolls et al., 1999; Verhagen et al., 2003). However, a number of studies have demonstrated the ability of components in fats, specifically free fatty acids, to activate taste cells and elicit behavioral responses consistent with there being a taste of fat. Here we show for the first time that long-chain unsaturated free fatty acid, linoleic acid (LA), depolarizes mouse taste cells and elicits a robust intracellular calcium rise via the activation of transient receptor potential channel type M5 (TRPM5). The LA-induced responses depend on G-protein-phospholipase C pathway, indicative of the involvement of G-protein-coupled receptors (GPCRs) in the transduction of fatty acids. Mice lacking TRPM5 channels exhibit no preference for and show reduced sensitivity to LA. Together, these studies show that TRPM5 channels play an essential role in fatty acid transduction in mouse taste cells and suggest that fatty acids are capable of activating taste cells in a manner consistent with other GPCR-mediated tastes. |
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Authors:
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Pin Liu; Bhavik P Shah; Stephanie Croasdell; Timothy A Gilbertson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-09 Completed Date: 2011-09-01 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 8634-42 Citation Subset: IM |
Affiliation:
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Department of Biology, Utah State University, Logan, Utah 84322, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Fatty Acids / metabolism* Food Preferences / physiology Male Mice Mice, Knockout Patch-Clamp Techniques Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / physiology TRPM Cation Channels / genetics, metabolism* Taste / physiology* Taste Buds / metabolism Type C Phospholipases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK059611/DK/NIDDK NIH HHS; R01 DC002507-08/DC/NIDCD NIH HHS; R01 DC002507-09/DC/NIDCD NIH HHS; R01 DC002507-10/DC/NIDCD NIH HHS; R01 DK059611-06/DK/NIDDK NIH HHS; R56 DK059611-05A1/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/TRPM Cation Channels; 0/Trpm5 protein, mouse; 7440-70-2/Calcium; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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