Document Detail

Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management.
MedLine Citation:
PMID:  24100669     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: Cold exposure activates brown adipose tissue (BAT), the major site of sympathetically activated nonshivering thermognenesis, via transient receptor potential (TRP) channels. Capsaicin and its nonpungent analogue (capsinoids) are agonists for a vanilloid subtype one of TRP, and have the potential to increase whole-body energy expenditure and reduce body fat. This article reviews the regulatory roles of BAT for energy expenditure and body fat in humans, particularly focusing on food ingredients activating the TRP-BAT axis.
RECENT FINDINGS: Acute cold exposure increased energy expenditure in humans with metabolically active BAT, but not those without it. Quite similar responses were found after a single oral ingestion of either capsinoids or an alcohol extract of Guinea pepper seeds, indicating that these food ingredients activate BAT and thereby increase energy expenditure. When individuals without active BAT were exposed to cold every day for 6 weeks, BAT was recruited in association with increased energy expenditure and decreased body fat. A 6-week daily ingestion of capsinoids mimicked the effects of repeated cold exposure. These findings indicate that human BAT can be reactivated/recruited, thereby increasing energy expenditure and decreasing body fat.
SUMMARY: Human BAT recruited by prolonged ingestion of a vanilloid subtype one of TRP agonists increases energy expenditure and decreases body fat. In addition to capsinoids, there are numerous food ingredients acting as TRP agonists, which are expected to activate BAT and so be useful for the prevention of obesity in daily life.
Takeshi Yoneshiro; Masayuki Saito
Related Documents :
20374789 - Biomarkers of meat intake and the application of nutrigenomics.
20054459 - Food choices and coronary heart disease: a population based cohort study of rural swedi...
17568059 - Food and nutrient intakes and k-ras mutations in exocrine pancreatic cancer.
19248869 - Increased sweetened beverage intake is associated with reduced milk and calcium intake ...
8120289 - Associations of social and demographic variables with calcium intakes of high school st...
15671239 - Determining the strength of the relationship between a food, food component, or dietary...
19700679 - Inulin-enriched dairy desserts: physicochemical and sensory aspects.
21934729 - The effects of dietary choline.
9498689 - Dietary strategies to improve the iron and zinc nutriture of young women following a ve...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-4
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  -     ISSN:  1473-6519     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartment of Anatomy, Hokkaido University Graduate School of Medicine bDepartment of Nutrition, Tenshi College, Sapporo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Amino acid transporters in the regulation of human skeletal muscle protein metabolism.
Next Document:  Iron and brain functions.