| Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly. | |
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MedLine Citation:
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PMID: 14976857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this report we describe the case of a 37-year-old white woman with Ebstein's anomaly, who developed a rare syndrome called platypnea-orthodeoxia, characterized by massive right-to-left interatrial shunting with transient profound hypoxia and cyanosis. This shunt of blood via a patent foramen ovale occurred in the presence of a normal pulmonary artery pressure, and was probably precipitated by a propafenone overdose. This drug caused biventricular dysfunction, due to its negative inotropic effect, and hypotension, due to its peripheral vasodilatory effect. These effects gave rise to an increase in the right atrial pressure and a decrease in the left one with a consequent stretching of the foramen ovale and the creation of massive right-to-left shunting. In our case this interatrial shunt was very accurately detected at bubble contrast echocardiography. |
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Authors:
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Daisy Pavoni; Sonia Ragazzo; Mauro Driussi; Francesco Antonini-Canterin; Daniela Pavan; Fabio Zardo; Gian Luigi Nicolosi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Italian heart journal : official journal of the Italian Federation of Cardiology Volume: 4 ISSN: 1129-471X ISO Abbreviation: Ital Heart J Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-02-23 Completed Date: 2004-04-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100909716 Medline TA: Ital Heart J Country: Italy |
Other Details:
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Languages: eng Pagination: 891-4 Citation Subset: IM |
Affiliation:
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Division of Cardiology, S. Maria degli Angeli Hospital, Pordenone, Italy. daisy_pav@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia / chemically induced*, diagnosis Anti-Arrhythmia Agents / administration & dosage*, adverse effects* Cyanosis / chemically induced*, diagnosis Dose-Response Relationship, Drug Ebstein Anomaly / drug therapy* Echocardiography Electrocardiography Female Heart Atria / drug effects, pathology, ultrasonography Heart Septal Defects, Atrial / chemically induced, diagnosis Heart Ventricles / drug effects, pathology, ultrasonography Humans Propafenone / administration & dosage*, adverse effects* Syndrome Tachycardia, Supraventricular / drug therapy Ventricular Dysfunction / chemically induced, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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