Document Detail


Transient partial response to sorafenib treatment in an adolescent patient with MEN2B Syndrome and end-stage medullary thyroid carcinoma.
MedLine Citation:
PMID:  21721105     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Metastatic medullary thyroid carcinoma (MTC) is an aggressive malignancy with an extremely poor prognosis. Currently no effective conventional systemic therapies exist to treat pediatric MTC. We describe an adolescent female with newly diagnosed MEN2B syndrome who presented with advanced stage metastatic MTC and demonstrated a partial transient response to sorafenib monotherapy. This clinical result supports further research into the use of sorafenib in the treatment of pediatric MTC. Pediatr Blood Cancer © 2011 Wiley-Liss, Inc.
Authors:
Steven Aller; Andrada Popescu; Sudha Rao; Elaine Morgan; Yasmin Gosiengfiao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-30
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  -     ISSN:  1545-5017     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Department of Pediatrics, Division of Hematology, Oncology, and Stem Cell Transplant, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
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