Document Detail

Transient pancytopenia after non-A non-B non-C acute hepatitis preceding acute lymphoblastic leukemia.
MedLine Citation:
PMID:  9676030     Owner:  NLM     Status:  MEDLINE    
Transient pancytopenia preceding childhood acute lymphoblastic leukemia (ALL) is an unfrequent but well-known event. The association of this preleukemic syndrome with hepatitis is extremely rare, with only two such cases having been published in the literature. We report the case of a 16-year-old boy who was diagnosed with B-cell type ALL that was preceded by transient pancytopenia with absent hemopoietic cells in the bone marrow following a seronegative hepatitis episode. The clinical, morphologic and immunophenotypic features of this patient are described and the literature on this preleukemic syndrome reviewed, with special emphasis being made on its differential diagnosis with hepatitis-associated aplastic anemia.
M Rafel; F Cobo; F Cervantes; F Bosch; E Campo; E Montserrat
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haematologica     Volume:  83     ISSN:  0390-6078     ISO Abbreviation:  Haematologica     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-08-11     Completed Date:  1998-08-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  564-6     Citation Subset:  IM    
Department of Hematology, Hospital Clínic, IDIBAPS, University of Barcelona, Spain.
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MeSH Terms
Anemia, Aplastic / complications*,  diagnosis*
Bone Marrow Transplantation
Diagnosis, Differential
Hepatitis, Viral, Human / complications*,  diagnosis*
Pancytopenia / complications*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*,  therapy
Remission Induction

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