| Transient outward potassium current in rabbit atrium is depressed after short-time rapid atrial pacing but recovers after a longer pacing period. | |
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MedLine Citation:
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PMID: 18981532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In rabbit, after short-time rapid atrial pacing (RAP), atrial ion currents are reduced similarly as in human chronic atrial fibrillation (AF). Using the rabbit model, time-course of transient outward potassium current (I(to)) remodeling due to RAP was studied. RAP (600 bpm) was applied via an atrial lead for 0 (control), 24 and 120 h, n = 4 animals/group. Using patch clamp technique in whole-cell mode, current densities and biophysical properties were measured in isolated atrial myocytes. After 24 h of RAP, a reduction of peak I(to) (mean +/- SEM, test potential +50 mV, +37 degrees C) was observed (60.3 +/- 5.4 pA/pF (control, n = 20) vs. 28.0 +/- 2.5 pA/pF (24 h, n = 21)). Inactivation of I(to) was slower after 24 h, other biophysical properties were unaltered. However, I(to) recovered after 120 h: 51.7 +/- 4.5 pA/pF (n = 26, p = n.s. vs. control). Inactivation tended to also recover to initial values but was still different to control. Early I(to) remodeling due to RAP in rabbits seems to be more complex than previously thought: a time course of I(to) remodeling with swayings has to be considered when using the rabbit model of RAP in order to study early remodeling or rather its therapeutic manipulation. |
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Authors:
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R Laszlo; C Eick; M Schwiebert; B Schreiner; H J Weig; S Weretka; J Schreieck |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: General physiology and biophysics Volume: 27 ISSN: 0231-5882 ISO Abbreviation: Gen. Physiol. Biophys. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-11-04 Completed Date: 2009-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8400604 Medline TA: Gen Physiol Biophys Country: Slovakia |
Other Details:
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Languages: eng Pagination: 174-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Tübingen, Otfried-Müller-Strasse 10, Tübingen, Germany. roman.laszlo@med.uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Function Calcium Channels / metabolism Cardiac Pacing, Artificial* Electric Conductivity* Heart Atria / metabolism* Potassium / metabolism* Potassium Channels / metabolism Rabbits Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Potassium Channels; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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