Document Detail

Transient and long-term differential modulations of branched-chain alpha-keto acid decarboxylase activity in hypophysectomized rats.
MedLine Citation:
PMID:  629995     Owner:  NLM     Status:  MEDLINE    
Hypophysectomy caused a marked but transient increase in branched-chain alpha-keto acid decarboxylase activities in rat liver mitochondria, peaking at about nine days post-surgery. The magnitude of increase is different for each of the three branched-chain alpha-keto acids. The activities then fall to a new steady state in three weeks with alpha-ketoisovalerate decarboxylase activity within the normal range, alpha-keto-beta-methylvalerate decarboxylase activity at twice normal, and alpha-ketoisocaproate decarboxylase activity decreased to a level too low for accurate measurements.
S G Sullivan; J Dancis; R P Cox
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  539     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
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MeSH Terms
Carboxy-Lyases / metabolism*
Hexanoic Acids / metabolism
Keto Acids / metabolism
Ketoglutaric Acids / metabolism
Mitochondria, Liver / enzymology
Pentanoic Acids / metabolism
Reg. No./Substance:
0/Hexanoic Acids; 0/Keto Acids; 0/Ketoglutaric Acids; 0/Pentanoic Acids; EC 4.1.1.-/Carboxy-Lyases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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