| Transient leukoencephalopathy after intrathecal methotrexate mimicking stroke. | |
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MedLine Citation:
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PMID: 21243392 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Methotrexate (MTX) is an indispensable antimetabolite for the treatment of oncological and immunological disorders in all age groups. It can be administrated intravenously as well as intrathecally and may be used alone or in combination with other drugs. Chronic leukoencephalopathy is a well-known side effect of MTX, especially in conjunction with intrathecal administration. However, acute neurotoxicity with confusion, disorientation, seizures, and focal deficits may also be seen. This can clinically mimic stroke with restricted diffusion on MRI. However, unlike stroke, there is resolution of clinical and imaging findings within 1-4 weeks. We report two cases of transient leukoencephalopathy following intrathecal methotrexate, with complete clinical and radiological resolutions on follow-up. |
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Authors:
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Amit Agarwal; Kanupriya Vijay; Krishnamoorthy Thamburaj; Tao Ouyang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-18 |
Journal Detail:
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Title: Emergency radiology Volume: - ISSN: 1438-1435 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431227 Medline TA: Emerg Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiology, Penn State University, Hershey Medical Center, 500 University Drive, Hershey, PA, 17036, USA, aagarwal1@hmc.psu.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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