Document Detail

Transient left ventricular dysfunction in ischaemic myocardium after stress: comparative study with exercise and pharmacological stress gated myocardial single photon emission computed tomography.
MedLine Citation:
PMID:  12717073     Owner:  NLM     Status:  MEDLINE    
In ischaemic heart disease patients, transient left ventricular dysfunction is observed due to post-exercise stunning. The aim of this study was to determine whether transient left ventricular dysfunction could also be seen after short-acting pharmacological stress (adenosine triphosphate). A 1 day rest/stress gated myocardial single photon emission computed tomography was performed on 362 patients suspected of having ischaemic heart disease by exercise (n=199) or short-acting pharmacological stress (n=163). Left ventricular ejection fraction were estimated both at rest and stress. Based on perfusion findings, patients were subdivided into ischaemia, fixed defect and normal group. For the ischaemia and fixed defect group, left ventricular ejection fraction after stress was significantly decreased compared with the resting value by exercise stress (ischaemia group, 57.5+/-11.0 vs 60.4+/-10.4; fixed defect group, 47.7+/-16.7 vs 49.6+/-16.8; P<0.01), but not by pharmacological stress (ischaemia group, 55.8+/-13.4 vs 57.1+/-13.8; fixed defect group, 50.8+/-13.5 vs 50.6+/-13.1; P=NS). In the normal group, left ventricular ejection fraction after stress was not significantly changed by either exercise (65.7+/-10.4 vs 66.8+/-10.2; P=NS) or pharmacological stress (63.0+/-11.7 vs 64.0+/-12.1; P=NS). It is concluded that a transient decrease in left ventricular ejection fraction after stress was observed following post-exercise, not following a short-acting pharmacological stress in patients showing perfusion abnormalities. Transient left ventricular dysfunction may be the result of post-exercise stunning, not from subendocardial hypoperfusion induced by short-acting pharmacological stress.
Y Iwado; H Furuyama; K Yoshinaga; M Mabuchi; Y Ito; K Noriyasu; T Kohya; A Kitabatake; E Tsukamoto; N Tamaki
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  24     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-28     Completed Date:  2004-02-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  551-7     Citation Subset:  IM    
Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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MeSH Terms
Adenosine Triphosphate / diagnostic use
Aged, 80 and over
Exercise Test
Gated Blood-Pool Imaging / methods*
Middle Aged
Myocardial Ischemia / complications,  diagnosis,  radionuclide imaging
Myocardial Stunning / complications*,  diagnosis,  radionuclide imaging*
Reference Values
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Stress, Physiological / chemically induced,  complications*
Ventricular Dysfunction, Left / diagnosis,  etiology*,  radionuclide imaging*
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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