Document Detail


Transient ischemic dilatation ratio derived from myocardial perfusion scintigraphy: What are we looking at?
MedLine Citation:
PMID:  20035391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Elevated transient ischemic dilatation (TID) ratio during myocardial perfusion imaging (MPI) is described as a marker of severe CAD, even in acquisitions with normal perfusion. This was initiated to explore the effects of stressor type on the TID. Additionally the relation between the TID and other functional parameters, such as end diastolic volume (EDV), end systolic volume (ESV), and left ventricle ejection fraction (LVEF), heart rate (HR), and severity of ischemia, was evaluated. METHOD: A total of 299 consecutive patients referred for a 2-day stress/rest MPI protocol were included. Patients were stressed with either adenosine (n = 164) or exercise (n = 135). MPI data were analyzed with an automated software tool to determine TID, EDV, ESV, LVEF, SSS, and SDS. The SDS was used to quantify the degree of ischemia, with a SDS > or = 3 considered ischemic. RESULTS: Comparison of the adenosine and exercise stressed population revealed significant differences, especially in parameters derived from the poststress acquisition. Within the exercise stressed population, TID was proportional with the SDS (R(2) = .12); whereas the adenosine population did not show such a relation (R(2) = .001). Difference in HR between rest and poststress acquisitions showed high levels of linear regression with TID values of both the adenosine (R(2) = .41) and exercise (R(2) = .29) stressed population. CONCLUSION: In an exercise stressed population, TID is determined by both the degree of ischemia and the heart-rate difference between the two acquisition moments. TID within the adenosine population was found to be highly proportional with the HR, rather than with the degree of ischemia.
Authors:
B J van der Veen; N Kuperij; M P M Stokkel
Publication Detail:
Type:  Journal Article     Date:  2009-12-25
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  17     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-15     Citation Subset:  IM    
Affiliation:
Division of Nuclear Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / metabolism
Aged
Automation
Coronary Artery Disease / radionuclide imaging
Exercise
Female
Heart / radionuclide imaging*
Heart Rate
Humans
Male
Middle Aged
Myocardial Ischemia*
Organophosphorus Compounds / chemistry
Organotechnetium Compounds / chemistry
Perfusion
Radionuclide Imaging / methods*
Retrospective Studies
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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