| Transient iodine organification defect in infants with ectopic thyroid glands. | |
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MedLine Citation:
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PMID: 8993866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Thyroid gland ectopy is the most common cause in infants with congenital hypothyroidism (CH). Its association with iodine organification defect, as suggested by positive perchlorate discharge test (PDT) has been reported. However, whether such an association represents a true or transient defect has not yet been determined. This finding has an important clinical, epidemiological, and genetic implications. OBJECTIVE: To determine the natural history of iodine organification defect in patients with CH caused by thyroid ectopy detected by neonatal screening. DESIGN: Prospective longitudinal study. Setting: King Khalid University Hospital, Riyadh, Saudi Arabia. PATIENTS AND METHODS: PDT was performed, at the time of diagnosis and follow-up, in infants who showed an enlarged ectopic thyroid gland with a Tc-99m pertechnetate uptake of 2% or more. RESULTS: Of 115 neonates with ectopic thyroid glands, 19 showed an enlarged gland with Tc-99m uptake ranging from 2 to 3.2%. Perchlorate discharge test was performed in 13 of these and was consistent with iodine organification defect in nine. Repeated PDT in seven patients showed normal values. CONCLUSION: The results of the authors' study indicate the transient nature of the iodine organification defect and suggest that a delay in the developmental of synthetic mechanisms occur in the dysgenetic glands. |
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Authors:
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N A al-Jurayyan; M I el-Desouki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 22 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-03-25 Completed Date: 1997-03-25 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 13-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Choristoma
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diagnosis*,
radionuclide imaging Congenital Hypothyroidism* Female Humans Hypothyroidism / diagnosis, etiology Infant, Newborn Male Neonatal Screening Perchloric Acid / diagnostic use Potassium Compounds / diagnostic use Prospective Studies Sodium Pertechnetate Tc 99m / diagnostic use Thyroid Function Tests Thyroid Gland* / radionuclide imaging Tongue Diseases / diagnosis*, radionuclide imaging |
| Chemical | |
Reg. No./Substance:
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0/Potassium Compounds; 23288-60-0/Sodium Pertechnetate Tc 99m; 7601-90-3/Perchloric Acid; 7778-74-7/potassium perchlorate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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