Document Detail

Transient iodine organification defect in infants with ectopic thyroid glands.
MedLine Citation:
PMID:  8993866     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thyroid gland ectopy is the most common cause in infants with congenital hypothyroidism (CH). Its association with iodine organification defect, as suggested by positive perchlorate discharge test (PDT) has been reported. However, whether such an association represents a true or transient defect has not yet been determined. This finding has an important clinical, epidemiological, and genetic implications.
OBJECTIVE: To determine the natural history of iodine organification defect in patients with CH caused by thyroid ectopy detected by neonatal screening.
DESIGN: Prospective longitudinal study.
SETTING: King Khalid University Hospital, Riyadh, Saudi Arabia.
PATIENTS AND METHODS: PDT was performed, at the time of diagnosis and follow-up, in infants who showed an enlarged ectopic thyroid gland with a Tc-99m pertechnetate uptake of 2% or more.
RESULTS: Of 115 neonates with ectopic thyroid glands, 19 showed an enlarged gland with Tc-99m uptake ranging from 2 to 3.2%. Perchlorate discharge test was performed in 13 of these and was consistent with iodine organification defect in nine. Repeated PDT in seven patients showed normal values.
CONCLUSION: The results of the authors' study indicate the transient nature of the iodine organification defect and suggest that a delay in the developmental of synthetic mechanisms occur in the dysgenetic glands.
N A al-Jurayyan; M I el-Desouki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  22     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-25     Completed Date:  1997-03-25     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
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MeSH Terms
Choristoma / diagnosis*,  radionuclide imaging
Congenital Hypothyroidism*
Hypothyroidism / diagnosis,  etiology
Infant, Newborn
Neonatal Screening
Perchlorates / diagnostic use
Potassium Compounds / diagnostic use
Prospective Studies
Sodium Pertechnetate Tc 99m / diagnostic use
Thyroid Function Tests
Thyroid Gland* / radionuclide imaging
Tongue Diseases / diagnosis*,  radionuclide imaging
Reg. No./Substance:
0/Perchlorates; 0/Potassium Compounds; 7778-74-7/potassium perchlorate; A0730CX801/Sodium Pertechnetate Tc 99m

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