Document Detail

Transient increase in renal epidermal growth factor content after unilateral nephrectomy in the mouse.
MedLine Citation:
PMID:  2003376     Owner:  NLM     Status:  MEDLINE    
A sensitive enzyme-linked immunosorbent assay for mouse epidermal growth factor was established for measurement of the content of epidermal growth factor in the remaining kidney after uninephrectomy. In 5-week-old male mice, the renal epidermal growth factor content before uninephrectomy was 355 +/- 97 ng/g wet tissue with a 2.1-fold increase on the first day after uninephrectomy, whereafter it gradually decreased. In 15-week-old mature male mice, the renal epidermal growth factor content increased 1.7-fold on the first day after uninephrectomy. Immunohistochemical analysis showed that epidermal growth factor was present in the distal tubular cells and that the staining intensity was increased on the first day after uninephrectomy. During the course of compensatory renal growth, no significant alteration of epidermal growth factor content was observed in plasma or in the submaxillary gland. Our data suggest that the increase in renal epidermal growth factor content after uninephrectomy is due to an increased production of epidermal growth factor in the kidney itself. The significance of this phenomenon is discussed.
S Kanda; P K Saha; K Nomata; M Taide; N Nishimura; T Igawa; J Yamada; H Kanetake; Y Saito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  124     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-04-12     Completed Date:  1991-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  188-93     Citation Subset:  IM    
Department of Urology, Nagasaki University School of Medicine, Japan.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay
Epidermal Growth Factor / metabolism*
Immunoenzyme Techniques
Kidney / metabolism*
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

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