Document Detail


Transient inactivation of orbitofrontal cortex blocks reinforcer devaluation in macaques.
MedLine Citation:
PMID:  22016546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The orbitofrontal cortex (OFC) and its interactions with the basolateral amygdala (BLA) are critical for goal-directed behavior, especially for adapting to changes in reward value. Here we used a reinforcer devaluation paradigm to investigate the contribution of OFC to this behavior in four macaques. Subjects that had formed associations between objects and two different primary reinforcers (foods) were presented with choices of objects overlying the two different foods. When one of the two foods was devalued by selective satiation, the subjects shifted their choices toward the objects that represented the nonsated food reward (devaluation effect). Transient inactivation of OFC by infusions of the GABA(A) receptor agonist muscimol into area 13 blocked the devaluation effect: the monkeys did not reduce their selection of objects associated with the devalued food. This effect was observed when OFC was inactivated during both satiation and the choice test, and during the choice test only. This supports our hypothesis that OFC activity is required during the postsatiety object choice period to guide the selection of objects. This finding sharply contrasts with the role of BLA in the same devaluation process (Wellman et al., 2005). Whereas activity in BLA was required during the selective satiation procedure, it was not necessary for guiding the subsequent object choice. Our results are the first to demonstrate that transient inactivation of OFC is sufficient to disrupt the devaluation effect, and to document a role for OFC distinct from that of BLA for the conditioned reinforcer devaluation process in monkeys.
Authors:
Elizabeth A West; Jacqueline T DesJardin; Karen Gale; Ludise Malkova
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-21     Completed Date:  2011-12-08     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15128-35     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Conditioning, Operant / drug effects,  physiology*
Discrimination (Psychology) / drug effects,  physiology
Eating / drug effects
Extinction, Psychological / drug effects,  physiology*
Feeding Behavior / drug effects
Female
GABA-A Receptor Agonists / administration & dosage
Imaging, Three-Dimensional
Macaca mulatta
Macaca nemestrina
Magnetic Resonance Imaging
Male
Muscimol / administration & dosage
Prefrontal Cortex / drug effects,  physiology*
Reinforcement (Psychology)*
Satiation / drug effects,  physiology
Time Factors
Grant Support
ID/Acronym/Agency:
F31 DA026705-01A2/DA/NIDA NIH HHS; F31DA026705/DA/NIDA NIH HHS; R21MH078277/MH/NIMH NIH HHS; T32DA007291/DA/NIDA NIH HHS; T32NS04123/NS/NINDS NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/GABA-A Receptor Agonists; 2763-96-4/Muscimol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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