Document Detail

Transient hypoxia: ventilatory response after vagotomy and during artificial phasic inflation.
MedLine Citation:
PMID:  34825     Owner:  NLM     Status:  MEDLINE    
The early ventilatory response to transient hypoxia was examined in the anaesthetized rabbit. In intact spontaneously breathing animals, an increase in tidal volume (VT) with an accompanying slight increase in inspiratory duration (TI) and a decrease in the expiratory duration (TE) was observed. After vagotomy, the ventilatory response was distinguished by a greater increase in VT and a significant decrease in TI and TE. In another group of artificially ventilated rabbits, an increase in inspiratory volume with a simultaneous decrease in breathing frequency was found to involve a smaller reflex increase in phrenic inspiratory discharge after onset of transient hypoxia. These observations suggest that afferents from pulmonary vagal stretch receptors inhibit those from arterial chemoreceptors.
S Delpierre; C Guillot; M Fornaris; Y Jammes; C Grimaud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  379     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-06-26     Completed Date:  1979-06-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM; S    
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MeSH Terms
Anoxia / blood,  physiopathology*
Carbon Dioxide / blood
Chemoreceptor Cells / physiology
Hydrogen-Ion Concentration
Lung / innervation*
Mechanoreceptors / physiology
Oxygen / blood
Phrenic Nerve / physiology
Vagus Nerve / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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