Document Detail

Transient hypothyroxinaemia in preterm infants.
MedLine Citation:
PMID:  17079099     Owner:  NLM     Status:  MEDLINE    
Thyroid hormones are required for normal development of the brain. Transient hypothyroxinaemia is the most common thyroid dysfunction in preterm infants and is defined by temporary low levels of T4, T3 and normal or low TSH. Low T4 levels in preterm infants are associated with persistent neurodevelopmental deficits in cognitive and motor function. Thyroid hormone substitution trials to date are underpowered and show inconsistent results; the question remains -- are low T4 levels simply an epiphenomenon? The aetiology of transient hypothyroxinaemia is multifactorial and the components amenable to correction form the basis of the therapeutic strategy: rectification of iodine deficiency in parenteral nutrition; a reduction of non-thyroidal illnesses and attenuation of their severity; and substitution of drugs that interfere with the hypothalamic-pituitary-thyroid axis. Thyroxine substitution therapy should only be done in the context of clinical trials and only in those infants who are hypothyroxinaemic.
Fiona L R Williams; Theo J Visser; Robert Hume
Related Documents :
2380819 - Longitudinal assessment of l-thyroxine therapy for congenital hypothyroidism.
24488749 - Incidence and impact of cmv infection in very low birth weight infants.
9642639 - The association of congenital hypothyroidism and congenital gastrointestinal anomalies ...
14695499 - A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism.
12012289 - Transient hypothyroxinemia of prematurity is associated with abnormal cranial ultrasoun...
263309 - 3,3',5'-triiodothyronine, thyroxine, triiodothyronine, and thyrotropin levels in matern...
6526369 - Urinary 3-methylhistidine derivative as indicator of nutrients intake in low-birth-weig...
11799699 - Breastfeeding is early functional jaw orthopedics (an introduction).
8561519 - Malaria in a rural area of sierra leone. i. initial results.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-10-31
Journal Detail:
Title:  Early human development     Volume:  82     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-10     Completed Date:  2007-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  797-802     Citation Subset:  IM    
Community Health Sciences, University of Dundee, Dundee, Scotland, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Hypothyroidism / blood*,  drug therapy,  etiology
Infant, Newborn
Infant, Premature / blood*
Thyrotropin / blood
Thyroxine / blood*,  therapeutic use
Triiodothyronine / blood*,  therapeutic use
Grant Support
//Wellcome Trust
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The impact of maternal smoking on fetal and infant growth.
Next Document:  Evaluation of HO-1-u-1 cell line as an in vitro model for sublingual drug delivery involving passive...