Document Detail

Transient hypotensive effect of phenytoin in man.
MedLine Citation:
PMID:  334808     Owner:  NLM     Status:  MEDLINE    
Phenytoin or an identically appearing placebo was administered in a double-blind fashion to 20 patients with mild essential hypertension. A significant fall in supine systolic blood pressure was noted 30 minutes to 1 hour after the oral administration of 100 mg phenytoin. No significant antihypertensive effect was observed after the patients had received 100 mg phenytoin every 8 hours for two weeks. Phenytoin had no effect on the diastolic blood pressure. It is concluded that the previously described hypotensive effect of phenytoin is a transient phenomenon which is of no therapeutic benefit in the long-term management of patients with essential hypertension.
J M Sullivan; H S Solomon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  17     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  607-11     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Drug Evaluation
Hypertension / drug therapy*
Middle Aged
Phenytoin / therapeutic use*
Reg. No./Substance:
0/Placebos; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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