Document Detail

Transient hepatic dysfunction in an infant of an epileptic mother treated with carbamazepine during pregnancy and breastfeeding.
MedLine Citation:
PMID:  1362364     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A case is reported of a carbamazepine (CBZ)-treated epileptic mother whose newborn presented with transient hepatic dysfunction characterized by direct hyperbilirubinemia and high concentrations of gamma-glutamyltransferase (GGT). DATA SOURCES: Information was obtained from case reports, clinical trials, and relevant bibliographic laboratory studies. DATA EXTRACTION: Data from case reports were evaluated and compared with those from our patient. The hepatotoxic reactions together with the microsomal enzymatic induction of CBZ were reviewed. DATA SYNTHESIS: A female infant born to an epileptic mother treated with CBZ throughout pregnancy and breastfeeding presented with transient direct hyperbilirubinemia and high concentrations of GGT. The characteristics of her transient hepatic dysfunction were: early appearance (during the first day of life); discrepancy between the normal liver enzymes and high GGT concentrations; slow decrease of GGT, which nevertheless remained at above-normal concentrations even after the complete disappearance of direct hyperbilirubinemia; and spontaneous resolution in spite of only occasional breastfeeding. The possible explanations of this transient hepatic dysfunction (like enzymatic induction) are discussed. CONCLUSIONS: CBZ-induced hepatic dysfunction in neonates appears to have different clinical expressions. Infants of epileptic mothers treated with CBZ throughout pregnancy and breastfeeding should be carefully monitored for possible adverse effects.
P Merlob; N Mor; A Litwin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  26     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-12     Completed Date:  1993-02-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1563-5     Citation Subset:  IM    
Department of Neonatology, Beilinson Medical Center, Petah Tiqva, Israel.
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MeSH Terms
Breast Feeding*
Carbamazepine / adverse effects*
Epilepsy / drug therapy*
Infant, Newborn
Jaundice, Neonatal / chemically induced*,  enzymology
Maternal-Fetal Exchange
Pregnancy Complications / drug therapy*
gamma-Glutamyltransferase / blood*
Reg. No./Substance:
298-46-4/Carbamazepine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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