| Transient global amnesia after taking sibutramine: a case report. | |
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MedLine Citation:
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PMID: 20220452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Sibutramine (Meridia in the United States, Reductil in Europe) is approved for weight reduction and weight maintenance. Although amnesia and seizure is listed as a reported adverse event of sibutramine in the US product information, our literature search in the PubMed website database found no published reports of theses adverse events. CASE REPORT: We report a 39-year-old healthy woman who had an episode of sudden memory loss lasting for several hours after taking sibutramine for 4 days. Cranial computed tomography scan, magnetic resonance imaging, and magnetic resonance angiography of the head all showed normal results. Electroencephalogram showed spike and wave complexes with phase reversal in the left mesial temporal area. Transient global amnesia was suspected clinically and transient epileptic amnesia provoked by sibutramine was also proposed. Three months after this episode, the follow-up electroencephalogram was normal. This patient did not take any anticonvulsant, and there were no more episodes of memory impairment. DISCUSSION: This case serves to emphasize that sibutramine which was used for weight reduction might induce transient global amnesia or provoke transient epileptic amnesia. Physicians should be careful to monitor for this adverse effect when sibutramine is prescribed. |
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Authors:
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Pin-Kuei Fu; Hung-Yi Hsu; Pao-Yu Wang |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The neurologist Volume: 16 ISSN: 1074-7931 ISO Abbreviation: Neurologist Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503763 Medline TA: Neurologist Country: United States |
Other Details:
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Languages: eng Pagination: 129-31 Citation Subset: IM |
Affiliation:
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Division of Neurology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Amnesia / chemically induced*, pathology, physiopathology Appetite Depressants / adverse effects*, therapeutic use Brain / drug effects, pathology, physiopathology Cyclobutanes / adverse effects*, therapeutic use Electroencephalography Female Follow-Up Studies Humans Magnetic Resonance Angiography Magnetic Resonance Imaging Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants; 0/Cyclobutanes; 106650-56-0/sibutramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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