Document Detail


Transient fetal myelosuppressive effect of D-penicillamine when used in pregnancy.
MedLine Citation:
PMID:  14676735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Normal fertility is sustained by progress in the medical therapy of Wilson's disease; however, pregnancy complications are encountered more frequently. The mother we present is a Wilson's disease patient who had been compliant with D-penicillamine for the preceding 13 years. She was admitted with unplanned pregnancy at the 16th gestational week. The dose of D-penicillamine could be reduced to 600 mg/d related to the underlying disease. Pregnancy ended with premature labor and delivery at the 29-30th weeks. The baby experienced type I respiratory distress and was treated by surfactant and mechanical ventilation. Neutropenia and leucopenia were documented at 6th postnatal hours. The baby showed neutropenia and leucopenia for 5 days and resolving without any further therapy. Intrauterine D-penicillamine was suspected to cause transient neonatal myelosuppression.
Authors:
M Yalaz; S Aydogdu; F Ozgenc; M Akisu; N Kultursay; R V Yagci
Related Documents :
18297615 - Maternal hydration status affects renal pelvic-calyceal diameter in pregnancy.
3737045 - Choriocarcinoma associated with ectopic pregnancy.
10366115 - Does rheumatoid arthritis remit during pregnancy and relapse postpartum? results from a...
17395115 - Pregnancy and contraceptive counseling of women with chronic kidney disease and kidney ...
11001815 - Maternal phenylketonuria: an international study.
3433635 - Anaesthesia in the pregnant guinea pig.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Minerva pediatrica     Volume:  55     ISSN:  0026-4946     ISO Abbreviation:  Minerva Pediatr.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-06-01     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  0400740     Medline TA:  Minerva Pediatr     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  IM    
Affiliation:
Neonatology Division, Department of Pediatrics, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chelating Agents / adverse effects*,  therapeutic use
Female
Fetal Diseases / chemically induced*
Hepatolenticular Degeneration / drug therapy
Humans
Infant, Newborn
Leukopenia / chemically induced*
Neutropenia / chemically induced*
Penicillamine / adverse effects*,  therapeutic use
Pregnancy
Pregnancy Complications / drug therapy
Chemical
Reg. No./Substance:
0/Chelating Agents; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Erythema nodosum induced by kerion celsi in a child with hypomelanosis of Ito
Next Document:  Induction of labour: which method to use?