Document Detail

Transient fetal myelosuppressive effect of D-penicillamine when used in pregnancy.
MedLine Citation:
PMID:  14676735     Owner:  NLM     Status:  MEDLINE    
Normal fertility is sustained by progress in the medical therapy of Wilson's disease; however, pregnancy complications are encountered more frequently. The mother we present is a Wilson's disease patient who had been compliant with D-penicillamine for the preceding 13 years. She was admitted with unplanned pregnancy at the 16th gestational week. The dose of D-penicillamine could be reduced to 600 mg/d related to the underlying disease. Pregnancy ended with premature labor and delivery at the 29-30th weeks. The baby experienced type I respiratory distress and was treated by surfactant and mechanical ventilation. Neutropenia and leucopenia were documented at 6th postnatal hours. The baby showed neutropenia and leucopenia for 5 days and resolving without any further therapy. Intrauterine D-penicillamine was suspected to cause transient neonatal myelosuppression.
M Yalaz; S Aydogdu; F Ozgenc; M Akisu; N Kultursay; R V Yagci
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Minerva pediatrica     Volume:  55     ISSN:  0026-4946     ISO Abbreviation:  Minerva Pediatr.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-16     Completed Date:  2004-06-01     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  0400740     Medline TA:  Minerva Pediatr     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  625-8     Citation Subset:  IM    
Neonatology Division, Department of Pediatrics, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
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MeSH Terms
Chelating Agents / adverse effects*,  therapeutic use
Fetal Diseases / chemically induced*
Hepatolenticular Degeneration / drug therapy
Infant, Newborn
Leukopenia / chemically induced*
Neutropenia / chemically induced*
Penicillamine / adverse effects*,  therapeutic use
Pregnancy Complications / drug therapy
Reg. No./Substance:
0/Chelating Agents; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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