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Transient expression of cellular retinol-binding protein-1 during cardiac repair after myocardial infarction.
MedLine Citation:
PMID:  22449228     Owner:  NLM     Status:  In-Data-Review    
Retinoic acid (RA) is a vitamin A derivative that exerts pleiotropic biological effects. Intracellular transport and metabolism of RA are regulated by cellular retinol-binding proteins (CRBP). CRBP-1 is transiently expressed in granulation tissue fibroblasts during wound healing; however, its role in cardiac remodeling remains unknown. A rat myocardial infarction (MI) model was established by ligation of the left coronary artery, and hearts were obtained at 3, 6, 15, 30 and 45 days after operation. Heart sections were examined immunohistochemically using anti-vimentin, anti-α-smooth muscle actin (α-SMA), anti-matrix metalloproteinase (MMP)-2, anti-MMP-9 and anti-CRBP-1 antibodies. Infarction involved 48.8 ± 3.6% of the left ventricle and was followed by an important cardiac remodeling. Vimentin-positive fibroblastic cells including α-SMA-positive myofibroblasts expressed CRBP-1 at 3-, 6-, and 15-days after MI. Expression of CRBP-1 reached a maximum at 6-days after infarction. Thereafter, CRBP-1 expression was dramatically decreased, showing a similar tendency to MMP expression. Human heart specimens of individuals with a recent myocardial infarction demonstrated presence of CRBP-1-positive fibroblasts by immunohistochemistry. We have demonstrated that CRBP-1 is transiently expressed by fibroblasts during cardiac remodeling. Our results suggest that CRBP-1 plays a role in ventricular remodeling after MI allegedly through its RA binding activity.
Mengyue Yu; Hatsue Ishibashi-Ueda; Keiko Ohta-Ogo; Giulio Gabbiani; Masakazu Yamagishi; Kenshi Hayashi; Seiichi Hirota; Marie-Luce Bochaton-Piallat; Hiroyuki Hao
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Publication Detail:
Type:  Journal Article     Date:  2012-03-04
Journal Detail:
Title:  Pathology international     Volume:  62     ISSN:  1440-1827     ISO Abbreviation:  Pathol. Int.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  246-53     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Pathology International © 2012 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
Department of Pathology, National Cerebral and Cardiovascular Center, Osaka Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan Department of Pathology and Immunology, University of Geneva-CMU, Geneva, Switzerland.
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