Document Detail

Transient expression of bile-duct-specific cytokeratin in fetal mouse hepatocytes.
MedLine Citation:
PMID:  7525069     Owner:  NLM     Status:  MEDLINE    
The differentiation of hepatocytes and biliary epithelial cells has been histochemically analyzed with anti-calf cytokeratin antiserum in the fetal mouse liver. Almost all young fetal hepatocytes transiently express bile-duct-specific cytokeratin; subsequently, the strong staining of the cytokeratin is confined to progenitor cells of intrahepatic biliary epithelial cells around portal veins. These results suggest that all fetal hepatocytes are bi-potent in terms of the differentiation of mature hepatocytes and intrahepatic bile-duct cells, and that the microenvironment around portal veins plays an important role in bile-duct differentiation. Large periportal hepatocytes continue to stain weakly for cytokeratin until 2 weeks after birth, although the number of positive hepatocytes decreases with development. The differentiation of bile ducts from periportal hepatocytes may continue for 2 weeks after birth.
N Shiojiri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell and tissue research     Volume:  278     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  IM    
Department of Biology, Faculty of Science, Shizuoka University, Japan.
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MeSH Terms
Albumins / analysis
Bile Ducts / embryology*
Cell Differentiation
Embryonic Induction
Fetal Proteins / analysis*
Keratins / biosynthesis*
Liver / cytology,  embryology,  metabolism*
Mice, Inbred C3H
Organ Specificity
Portal Vein
Stem Cells / metabolism
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Albumins; 0/Fetal Proteins; 0/alpha-Fetoproteins; 68238-35-7/Keratins

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