Document Detail


Transient expression of bile-duct-specific cytokeratin in fetal mouse hepatocytes.
MedLine Citation:
PMID:  7525069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The differentiation of hepatocytes and biliary epithelial cells has been histochemically analyzed with anti-calf cytokeratin antiserum in the fetal mouse liver. Almost all young fetal hepatocytes transiently express bile-duct-specific cytokeratin; subsequently, the strong staining of the cytokeratin is confined to progenitor cells of intrahepatic biliary epithelial cells around portal veins. These results suggest that all fetal hepatocytes are bi-potent in terms of the differentiation of mature hepatocytes and intrahepatic bile-duct cells, and that the microenvironment around portal veins plays an important role in bile-duct differentiation. Large periportal hepatocytes continue to stain weakly for cytokeratin until 2 weeks after birth, although the number of positive hepatocytes decreases with development. The differentiation of bile ducts from periportal hepatocytes may continue for 2 weeks after birth.
Authors:
N Shiojiri
Related Documents :
11844709 - Synthesis and cytotoxicity of 3,4-diaryl-2(5h)-furanones.
20886009 - Laparoscopic splenectomy for hairy cell leukemia in pregnancy.
9047009 - Dual expression of prolactin-related protein in decidua and trophoblast tissues during ...
25457839 - Pregnancy level of estrogen attenuates experimental autoimmune encephalomyelitis in bot...
18584409 - Nitric oxide detection by daf (diaminofluorescein) fluorescence in human myometrial tis...
18972319 - Prognostic subgroup distribution in diffuse large b-cell lymphoma of the upper aerodige...
10589049 - Comparison of nuchal translucency measurement and mid-gestation serum screening in assi...
8231899 - Synthesis of gap junction proteins and collagenases in the preimplantation rat uterus.
1788179 - First-trimester diagnosis of hypophosphatasia. importance of gestational age and purity...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell and tissue research     Volume:  278     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  IM    
Affiliation:
Department of Biology, Faculty of Science, Shizuoka University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Albumins / analysis
Animals
Bile Ducts / embryology*
Cell Differentiation
Embryonic Induction
Fetal Proteins / analysis*
Keratins / biosynthesis*
Liver / cytology,  embryology,  metabolism*
Mice
Mice, Inbred C3H
Morphogenesis
Organ Specificity
Portal Vein
Stem Cells / metabolism
alpha-Fetoproteins / analysis
Chemical
Reg. No./Substance:
0/Albumins; 0/Fetal Proteins; 0/alpha-Fetoproteins; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose strep...
Next Document:  Comparative study of immature erythroid cells of the diploid Bufo ictericus and the tetraploid Odont...