Document Detail

Transient elevation of pulmonary arterial pressure induced by sublingual angiotensin converting enzyme inhibitors.
MedLine Citation:
PMID:  7938398     Owner:  NLM     Status:  MEDLINE    
Twelve patients with ischemic heart disease had complete left and right catheterization before and after sublingual captopril. Hemodynamic measurements were ten (10) minutes apart and were monitored for thirty (30) minutes. The heart rate increased from 70 +/- 13 to 76 +/- 11 beats/minute (P = .04). There was no change in the arterial blood pressure, although the systemic vascular resistance decreased from 1500 +/- 400 to 1026 +/- 480 dynes-sec-cm-5 (P < .0001). The pulmonary artery pressure was increased 15 +/- 6 to 25 +/- 5mmHg (P = .005) and the pulmonary vascular resistance increased from 288 + 160 to 376 + 160 dynes-sec-cm-5 (P < .0001). The wedge pressure increased from 7 +/- 2 to 14 +/- 3 mmHg (P = .05). The cardiac output (CO) increased from 5.06 +/- 1.06 to 578 +/- 1.58 Lt/min. (P.05 =. The left ventricular end diastolic volume (LVEDV) increased from 128 +/- 40 to 145 +/- 37cc)P = .002), without change in the end systolic volume (ESV). The ejection fraction (EF) increased from 56 +/- 3 to 61 +/- 4% (P = .02). These pressure changes appeared at two (2) minutes and disappeared after thirty (30) minutes. The study shows that, sublingual captopril produces a transient elevation of the pulmonary artery pressure and resistance.
P I Altieri; W Silva; H Méndez; H L Banchs
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Puerto Rico health sciences journal     Volume:  13     ISSN:  0738-0658     ISO Abbreviation:  P R Health Sci J     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-10     Completed Date:  1994-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8303541     Medline TA:  P R Health Sci J     Country:  PUERTO RICO    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Department of Medicine, University of Puerto Rico, Río Piedras.
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MeSH Terms
Administration, Sublingual
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  pharmacology*
Blood Pressure / drug effects*
Captopril / administration & dosage,  pharmacology
Heart Catheterization
Middle Aged
Myocardial Ischemia / physiopathology*
Pulmonary Artery / physiopathology*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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