Document Detail


Transient elastography in the assessment of liver fibrosis in adult thalassemia patients.
MedLine Citation:
PMID:  20658587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient elastography (TE) is a valuable noninvasive technique of measuring liver stiffness and a reliable tool for predicting hepatic fibrosis in patients with chronic liver disease. The role of TE in patients with beta-thalassemia has not been extensively investigated. The present study aimed to evaluate the role of TE in the assessment of hepatic fibrosis in 115 adult patients with beta-thalassemia major (TM) (#59) or intermedia (TI) (#56). TE was performed according to current practice. Histologic data were obtained in 14 cases. Liver iron concentration was assessed by atomic absorption spectrometry and T2 magnetic resonance. In patients with TM, the proportion of anti-HCV positive viremic patients, median serum ferritin levels, and TE values were significantly higher than in TI. In the group of 14 patients who underwent liver biopsy, a significant positive correlation was observed between liver stiffness and fibrosis stage (r = 0.73, P = 0.003). Severe fibrosis is diagnosed with a sensitivity of 60% and a specificity of 89%, whereas cirrhosis is detected with a sensitivity of 100% and a specificity of 92%. At multivariate analysis, the variables independently associated with TE were ALT, GGT, and bilirubin levels in both groups and, in patients with TM, HCV RNA positivity. In beta-thalassemia patients, TE is a reliable tool for assessing liver fibrosis even if the influence of iron overload has to be clarified.
Authors:
Mirella Fraquelli; Elena Cassinerio; Alberto Roghi; Cristina Rigamonti; Giovanni Casazza; Massimo Colombo; Sara Massironi; Dario Conte; Maria Domenica Cappellini
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  85     ISSN:  1096-8652     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  564-8     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Affiliation:
Second Division of Gastroenterology, Foundation IRCCS Cà Granda, Maggiore Policlinico Hospital and University of Milan, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Transfusion / adverse effects
Cohort Studies
Cross-Sectional Studies
Elasticity
Elasticity Imaging Techniques*
Female
Ferritins / analysis
Hepatitis C, Chronic / complications,  pathology
Humans
Iron / therapeutic use
Iron Overload / etiology,  pathology
Italy
Liver / chemistry,  pathology*
Liver Cirrhosis / diagnosis,  etiology,  pathology*
Male
Middle Aged
Observer Variation
Single-Blind Method
Viremia / complications
Young Adult
beta-Thalassemia / complications*
Chemical
Reg. No./Substance:
7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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