Document Detail

Transient cochlear ischemia and its effects on the stria vascularis.
MedLine Citation:
PMID:  15891573     Owner:  NLM     Status:  MEDLINE    
The effects of transient cochlear ischemia on the stria vascularis were studied. Fifteen minutes of ischemia decreased the endocochlear potential by up to 17.5 mV on day 1; it returned to normal on day 7. Immunostaining for Na+,K+-ATPase, a marker for the Na+/K+-pump, and for connexin 26, a marker for gap junctions, was inhibited on days 1 and 4, and returned to normal on day 7. Electron microscopy showed expansion of the intercellular space with abundant vacuolar formation in the stria vascularis. These morphological changes disappeared completely by day 7. The results indicate that transient ischemia causes a reversible functional disorder of the stria vascularis with fine structural changes, which may be owing to dysfunction of Na+/K+-pump or gap junctions.
Isao Morizane; Nobuhiro Hakuba; Yoshitaka Shimizu; Yusuke Shinomori; Kensuke Fujita; Tadashi Yoshida; Masachika Shudou; Kiyofumi Gyo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  16     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-13     Completed Date:  2005-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-802     Citation Subset:  IM    
Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan.
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MeSH Terms
Cochlear Diseases / metabolism,  physiopathology*
Cochlear Microphonic Potentials / physiology*
Connexins / metabolism
Immunohistochemistry / methods
Ischemic Attack, Transient / metabolism,  physiopathology*
Microscopy, Electron, Transmission / methods
Sodium-Potassium-Exchanging ATPase / metabolism
Stria Vascularis / pathology,  physiology*,  ultrastructure
Time Factors
Reg. No./Substance:
0/Connexins; 127120-53-0/connexin 26; EC ATPase

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