Document Detail

Transient changes in energy metabolites and intracellular pH during spreading depression in the chick retina.
MedLine Citation:
PMID:  1749366     Owner:  NLM     Status:  MEDLINE    
The in vitro preparation of the chick retina can be used to show the occurrence of transient changes in the intracellular pH and of energy metabolites which occurs during spreading depression (SD). There is an initial increase in intracellular pH associated with elevated values for ADP, P-Creatine, lactate and pyruvate, an intermediary acid shift with increases in ATP values and decreases in ADP, and a late alkaline rebound where P-Creatine levels are reduced and the content of ADP and lactate are elevated. These transient changes in intracellular pH observed during SD, when correlated to the levels of energy metabolites, supports the hypothesis that the intracellular pH can be used by the tissue as a mechanism to rapidly modify the metabolic activities of neurons and glial cells. We suggest that the first alkaline shift is caused by glial cells and the intermediary acid shift by neurons. However, a specific cell could not be pointed out as responsible for the late alkaline shift but it could explain the refractoriness of the neurons during the phenomenon.
F A de Azeredo
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Metabolic brain disease     Volume:  6     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Laboratorio de Biociencias, Universidade Federal Fluminense, Niteroi, Brazil.
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MeSH Terms
Adenosine Diphosphate / metabolism
Adenosine Triphosphate / metabolism
Cortical Spreading Depression / physiology*
Creatine / metabolism
Creatine Kinase / metabolism
Energy Metabolism / physiology*
Hydrogen-Ion Concentration
Neuroglia / metabolism
Neurons / metabolism
Retina / metabolism*
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 57-00-1/Creatine; 58-64-0/Adenosine Diphosphate; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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