Document Detail

Transient changes in blood pressure during spontaneous deep breaths in rats with sinoaortic deafferentation.
MedLine Citation:
PMID:  1568987     Owner:  NLM     Status:  MEDLINE    
Sinoaortic deafferentation (SAD) in rats produces moderate increases in mean arterial pressure (MAP) along with a large augmentation of arterial pressure lability (APL). The mechanisms generating this APL are incompletely understood. To study the possible influence of breathing activity on APL in conscious SAD rats, we simultaneously recorded pulmonary ventilation and arterial blood pressure. The general pattern of pulmonary ventilation was the same in normal, sham-operated, and SAD rats. In all groups single large tidal volumes were regularly interposed in 1- to 2-min periods of shallower breathing. In SAD rats these single large inspirations were consistently accompanied by substantial and abrupt reductions of MAP, whereas this effect was markedly smaller or absent in normal and sham-operated rats. The data reflect the lack of fast moment-to-moment control of arterial pressure normally exerted by the aortic and carotid baroreceptors. In this context, effects of ventilatory changes must be considered along with humoral and neurogenic factors to explain APL after SAD.
B H Machado; H Mauad; M L Glass
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  72     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-27     Completed Date:  1992-05-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  920-4     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
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MeSH Terms
Blood Pressure / physiology*
Hemodynamics / physiology
Pressoreceptors / physiology
Rats, Inbred Strains
Respiratory Mechanics / physiology*
Sinoatrial Node / physiology

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