| Transient catabolic state with reduced IGF-I after antenatal glucocorticoids. | |
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MedLine Citation:
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PMID: 17622956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucocorticoid (GC) administration before preterm birth reduces neonatal morbidity but may restrain growth. Here we explored the effect of antenatal GC on nutrient substrates [glucose, FFA, amino acids (AA)], and on IGF-I and IGF-binding protein-1 (IGFBP-1). We analyzed umbilical vein (UV) plasma obtained at birth from 91 preterm newborns that received one course of GC (last exposure 1-1358 h before birth) and 49 newborns that did not. We found that recent GC exposure (-48 h) raised glucose, FFA, and AA concentrations, and the homeostasis model assessment of insulin resistance (HOMA-IR) index, but lowered IGF-I concentrations. The AA surge was greater in newborns with a birth weight z score <0 than in those with a z score >0. Although all AA were transiently increased, the increment was most robust for glutamine and alanine. Shorter duration since GC administration and lower IGF-I concentrations independently predicted AA levels. In conclusion, an antenatal course of GC elicited a transient catabolic state encompassing all nutrient substrates, and a temporary drop in IGF-I concentrations. These changes may explain the growth-inhibitory effects of repeated antenatal GC administration. Future research should clarify the role of IGF-I in the protein-catabolic response to GC. |
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Authors:
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Johan Verhaeghe; Florent Vanstapel; Rita Van Bree; Erik Van Herck; Willy Coopmans |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 62 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-12-05 Completed Date: 2008-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 295-300 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Health Campus Gasthuisberg, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. johan.verhaeghe@uz.kuleuven.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood Birth Weight Blood Glucose / metabolism Fatty Acids, Nonesterified / blood Female Fetal Blood / chemistry Fetus / drug effects*, physiology Glucocorticoids / pharmacology* Homeostasis Humans Infant, Newborn Insulin-Like Growth Factor Binding Protein 1 / metabolism* Insulin-Like Growth Factor I / metabolism* Male Pregnancy Premature Birth* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Glucocorticoids; 0/Insulin-Like Growth Factor Binding Protein 1; 67763-96-6/Insulin-Like Growth Factor I |
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