Document Detail


Transient alkaline hyperphosphatasaemia in an adult: biochemical peculiarities.
MedLine Citation:
PMID:  9228327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report on a 27-year-old healthy female with transient hyperphosphatasaemia of adulthood (it is the eighth case ever recorded). A maximum alkaline phosphatase activity of 1950 U/l, 11-fold the upper reference limit, was measured. The activity normalized within 11 weeks. Electrophoresis revealed the typical pattern for alkaline phosphatase isoenzymes observed in transient hyperphosphatasaemia of infancy: a fast-migrating liver isoenzyme and a bone isoenzyme. Contrary to the findings in transient hyperphosphatasaemia of infancy the liver isoenzyme did not precipitate with wheat-germ lectin whereas the bone isoenzyme partially bound to lectin. Biochemical features of transient hyperphosphatasaemia in an adult may be different from those in infancy. Recognition of an atypical pattern could help avoid unnecessary extensive investigations.
Authors:
C M Schambeck; A Kopp; G Mora-Maza; F Keller
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies     Volume:  35     ISSN:  0939-4974     ISO Abbreviation:  Eur J Clin Chem Clin Biochem     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-09-22     Completed Date:  1997-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105775     Medline TA:  Eur J Clin Chem Clin Biochem     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  441-4     Citation Subset:  IM    
Affiliation:
Zentrallabor der Medizinischen Klinik, Bayerische Julius-Maximilians-Universität Würzburg, Germany. c.schambeck@medizin.uni-wuerzburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkaline Phosphatase / analysis,  blood*,  isolation & purification
Blood Protein Electrophoresis
Bone and Bones / enzymology
Female
Humans
Infant
Isoenzymes / analysis,  blood*,  isolation & purification
Liver / enzymology
Male
Wheat Germ Agglutinins
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Wheat Germ Agglutinins; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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