Document Detail


Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus.
MedLine Citation:
PMID:  23940359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the cochlear nucleus (CN), the first central relay of the auditory pathway, the survival of neurons during the first weeks after birth depends on afferent innervation from the cochlea. Although input-dependent neuron survival has been extensively studied in the CN, neurogenesis has not been evaluated as a possible mechanism of postnatal plasticity. Here we show that new neurons are born in the CN during the critical period of postnatal plasticity. Coincidently, we found a population of neural progenitor cells that are controlled by a complex interplay of Wnt, Notch, and TGFβ/BMP signaling, in which low levels of TGFβ/BMP signaling are permissive for progenitor proliferation that is promoted by Wnt and Notch activation. We further show that cells with activated Wnt signaling reside in the CN and that these cells have high propensity for neurosphere formation. Cochlear ablation resulted in diminishment of progenitors and Wnt/β-catenin-active cells, suggesting that the neonatal CN maintains an afferent innervation-dependent population of progenitor cells that display active canonical Wnt signaling.
Authors:
Stefan Volkenstein; Kazuo Oshima; Saku T Sinkkonen; C Eduardo Corrales; Sam P Most; Renjie Chai; Taha A Jan; Renée van Amerongen; Alan G Cheng; Stefan Heller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-08-12
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  110     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-28     Completed Date:  2013-11-22     Revised Date:  2014-04-22    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14456-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Cochlear Nucleus / cytology,  physiology*
Mice
Mice, Inbred C57BL
Neural Stem Cells / cytology,  physiology*
Neurogenesis
Grant Support
ID/Acronym/Agency:
DC006167/DC/NIDCD NIH HHS; DC010042/DC/NIDCD NIH HHS; DC11043/DC/NIDCD NIH HHS; K08 DC011043/DC/NIDCD NIH HHS; P30 DC010363/DC/NIDCD NIH HHS
Comments/Corrections
Erratum In:
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):1760
Note: van Amerongen, Renée [added]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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