| Transient acquired resistance to the coumarin anticoagulants phenprocoumon and acenocoumarol. | |
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MedLine Citation:
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PMID: 542805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 62-year-old man developed resistance to coumarin congeners during treatment with phenprocoumon (Marcoumar) and acenocoumarol (Sintrom), requiring at least triple the usual therapeutic dose and plasma concentration of phenprocoumon for satisfactory anticoagulation. After 8 months on this high dosage, the patient suddenly developed haemorrhagic diathesis. The medication was therefore discontinued. The resistance could not be ascribed to impaired absorption or enhanced metabolism. |
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Authors:
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F A de Wolff; J W ten Cate |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Scandinavian journal of haematology Volume: 23 ISSN: 0036-553X ISO Abbreviation: Scand J Haematol Publication Date: 1979 Nov |
Date Detail:
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Created Date: 1980-06-25 Completed Date: 1980-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404507 Medline TA: Scand J Haematol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 437-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Hydroxycoumarins
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therapeutic use* Acenocoumarol / adverse effects, metabolism, therapeutic use* Drug Resistance Hemorrhagic Disorders / chemically induced Humans Male Middle Aged Phenprocoumon / adverse effects, metabolism, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/4-Hydroxycoumarins; 152-72-7/Acenocoumarol; 435-97-2/Phenprocoumon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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