Document Detail

Transient Receptor Potential Channels as Targets for Phytochemicals.
MedLine Citation:
PMID:  24926802     Owner:  NLM     Status:  Publisher    
To date, twenty eight mammalian transient receptor potential (TRP) channels have been cloned and characterized. They are grouped into six subfamilies on the basis of their amino acid sequence homology: TRP Ankyrin (TRPA), TRP Canonical (TRPC), TRP Melastatin (TRPM), TRP Mucolipin (TRPML), TRP Polycystin (TRPP) and TRP Vanilloid (TRPV). Most of the TRP channels are non-selective cation channels expressed on the cell membrane and exhibit variable permeability ratios for Ca2+ versus Na+. They mediate sensory functions (such as vision, nociception, taste transduction, temperature sensation and pheromone signaling) and homeostatic functions (such as divalent cation flux, hormone release and osmoregulation). Significant progress has been made in our understanding of the specific roles of these TRP channels and their activation mechanisms. In this review, the emphasis will be on the activation of TRP channels by phytochemicals that are claimed to exert health benefits. Recent findings complement the anecdotal evidences that some of these phytochemicals have specific receptors and the activation of which are responsible for the physiological effects. Now, the targets for these phytochemicals are being unveiled; a specific hypothesis can be proposed and tested experimentally to infer a scientific validity of the claims of the health benefits. The broader and pressing issues that have to be addressed are the quantities of the active ingredients in a given preparation, their bioavailability, metabolism, adverse effects, excretion and systemic versus local effects.
Louis S Premkumar
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-13
Journal Detail:
Title:  ACS chemical neuroscience     Volume:  -     ISSN:  1948-7193     ISO Abbreviation:  ACS Chem Neurosci     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525337     Medline TA:  ACS Chem Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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