Document Detail


Transient neonatal myasthenia gravis revealing a myasthenia gravis and a systemic lupus erythematosus in the mother: case report and review of the literature.
MedLine Citation:
PMID:  19488958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient neonatal myasthenia gravis (TNMG) and neonatal lupus are rare conditions due to the transplacental passage of antibodies. We describe a unique case of TNMG, revealing a myasthenia gravis (MG) associated with systemic lupus erythematosus (SLE) in the mother. J. M., 8 days of age, was admitted for jaundice. Examination revealed poor sucking, facial weakness, and hypotonicity. TNMG was confirmed with a high level of antiacetylcholine receptor antibodies in the infant and his mother. No sign of neonatal lupus was observed. Clinical recovery was obtained. The elder brother had autism. In case of previous maternal MG, a low percentage of infants develop TNMG (10 to 20%), but monitoring is required at birth. Improvement is usually obtained within 3 weeks. No correlation has been found between maternal symptoms, antibodies titer, and signs of TNMG. Most cases of neonatal lupus are associated with positive anti-SSA/SSB antibodies in the mother. Both conditions, MG and SLE, are reported, but pregnancies are very few. Autism in the brother focuses on its relationship with immune diseases.
Authors:
Marie Saint-Faust; Serge Perelman; Didier Dupont; Patrick Velin; Marcel Chatel
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-06-01
Journal Detail:
Title:  American journal of perinatology     Volume:  27     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers.
Affiliation:
Paediatrics, University Hospital Pasteur, Nice, France. mariestfaust@hotmail.fr
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antinuclear / blood
Female
HLA Antigens / genetics
Haplotypes
Humans
Infant, Newborn
Lupus Erythematosus, Systemic / diagnosis*,  immunology
Male
Myasthenia Gravis / diagnosis*
Myasthenia Gravis, Neonatal / complications*
Pregnancy
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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