Document Detail


Transient leukemia in newborns without down syndrome: diagnostic and management challenges.
MedLine Citation:
PMID:  21768885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient leukemia (TL), defined by circulating nonlymphoid blast in the peripheral blood, occurs in approximately 10% of infants with constitutional trisomy 21 (Down syndrome). The TL phenotype may also occur in newborns who do not have clinical signs of Down syndrome but nonconstitutional trisomy 21 due to mosaicism. We report the cases of 3 infants to highlight the specific parental concerns, diagnostic and counseling requirements for this group of infants and their families and suggest a practical approach to diagnosis, follow-up, anticipatory guidance, and discussion of prognosis for families with newborns diagnosed with TL and nonconstitutional trisomy 21.
Authors:
Brent A Williams; M Stephen Meyn; Johann K Hitzler
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  33     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-09-27     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e261-3     Citation Subset:  IM    
Affiliation:
Division of Hematology/Oncology, Hospital for Sick Children, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 21 / genetics*
Female
Humans
In Situ Hybridization, Fluorescence
Infant, Newborn
Leukemia / diagnosis*,  genetics*,  psychology
Male
Mosaicism
Prognosis
Trisomy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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