Document Detail

Transient HTLV-I infection of a human glioma cell line following cell-free exposure.
MedLine Citation:
PMID:  8249298     Owner:  NLM     Status:  MEDLINE    
The human T-lymphotropic virus type I (HTLV-I) has been recently associated with cases of tropical spastic paraparesis and human myelopathy. In order to study whether cells of neuroectodermic origin were susceptible to HTLV-I infection, a human glioma cell line T67 was exposed in vitro to HTLV-I by a cell-free method of virus transmission. The presence of HTLV-I proviral DNA was analyzed by polymerase chain reaction 3, 7, and 14 days after infection. The results showed the presence of LTR, pol, and tax sequences within glioma cell line 3 days after the infection. However after 7 and 14 days, detection of HTLV-I sequences remarkably decreased. P19 expression peaked 7 days after infection and decreased in the following week. These data provide evidence that cell-free transmission of HTLV-I results in transient infection of cells of glial origin.
G Graziani; I Faraoni; J Zhang; B Caronti; G Lauro; E Bonmassar; B Macchi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virology     Volume:  197     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1993-12-23     Completed Date:  1993-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  767-9     Citation Subset:  IM; X    
Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.
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MeSH Terms
DNA, Viral / analysis
Gene Products, gag / biosynthesis
HTLV-I Antigens / biosynthesis
Human T-lymphotropic virus 1 / genetics,  growth & development*
Monocytes / microbiology
Neuroglia / microbiology*
Polymerase Chain Reaction
Proviruses / genetics
Retroviridae Proteins, Oncogenic / biosynthesis
Tumor Cells, Cultured
gag Gene Products, Human Immunodeficiency Virus
Reg. No./Substance:
0/DNA, Viral; 0/Gene Products, gag; 0/HTLV-I Antigens; 0/Retroviridae Proteins, Oncogenic; 0/gag Gene Products, Human Immunodeficiency Virus; 0/p19 protein, Human T-lymphotropic virus 1

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